• Pushpendra Kumar Jain S O A University , Bhuvaneshwar ( India)
  • Singhai Ak
  • Debajyoti Das
  • Pushpendra Kumar Jain


Objective: The main objective of present study is to treat Alopecia. Alopecia areata is an unpredictable hair-loss condition. Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. Herbal systems of medicine have become increasingly popular in recent years. Medicinal plants have been used for the treatment of hair diseases since antiquity. Herbs such as turmeric, fenugreek, ginger, Cyperus rotundus (Nagarmotha), and holy basil are integral parts of ayurvedic formulations. Cyperus rotundus is a well-known ayurvedic herb with purported claims of hair growth promotion.


Methods: Extracts are prepared by separating the soluble matter from vegetable tissues by the application of a suitable solvent such as alcohol, water, or ether. The resultant liquid is concentrated by evaporation to obtain a liquid extract or concentrated almost to dryness to obtain the solid extract and its volatile oil. Hair formulation of Cyperus rotundus belonging to family Cyperaceae in the form of herbal formulation (5% herbal cream and oil) was studied and it showed excellent hair growth activity with standard (2% minoxidil ethanolic solution) in Wister albino rats.


Results: Hair growth initiation time was significantly reduced to half on treatment with the oil, as compared to control animals. The hair growth promoting effect was evaluated against the control, standard, and test animals at 0, 10, 15, and 20 days with the formulated hair oil and hair cream prepared from the volatile oil extracted from the Cyperus rotundus and the significant hair growth was observed, and the growth was compared with the standard drug used 2% solution of minoxidil.


Conclusion: The results of treatment with oil were better than the positive control minoxidil 2% treatment. It holds the promise of potent herbal alternative for minoxidil.


Keywords: Alopecia areata, Cyperus rotundus, Hair growth, Extracts, Herbal creams, Hair oil, Hair formulation, Ayurvedic, Cyperaceae.




Author Biography

Pushpendra Kumar Jain, S O A University , Bhuvaneshwar ( India)

Faculty of Pharmacy



Butler H. Poucher’s Perfumes, Cosmetics and Soaps. 9th ed., Vol. III.

London: Chapman and Hall; 1993. p. 130.

Olsen EA, Weiner MS, Amara IA, DeLong ER. Five-year follow-up of

men with androgenetic alopecia treated with topical minoxidil. J Am

Acad Dermatol 1990;22(4):643-6.

Wilson C, Walkden V, Powell S. British Journal of Acad Dermatology.

Br J Acad Dermatol 1991;24:661.

Bhalerao SS, Solanki NH. Therapeutic approaches to management of

common baldness. Indian Drugs 2002;39(11):567.

Kokate CK, Purohit AP, Gokhale SB. In: Pharmacogonosy. 19th ed.

Pune: Nirali Prakashan; 2002. p. 224.

Fig. 1: Hair growth result at 0 day

Fig. 2: Hair growth initiation result at 6 days using HF2


Fig. 3: Hair growth result at 20th day using HF2 formulation

Fig. 4: Cycle of scalp-hair growth

Shah CS, Qudry JS. A Text Book of Pharmacognosy. 11th ed.

Ahmedabad: B.S. Shah Prakashan; 1996. p. 119.

Evans WC. Trease and Evans Pharmacognosy. 15th ed. Elsevier

(A Division of Reed Elsevier India Pvt. Limited): W.B. Saunders

Harcourt Publishers Ltd.; 2002. p. 292.

Kritikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. Allahabad: Lalit

Mohan Basu; 1999. p. 472.

The Ayurvedic Formulary of India, Government of India. Ministry of

Health and Family Planning. 1st ed. Delhi: Department of Health; 1978.

p. 99.

Pharmacopoeia of India. Government of India, Ministry of

Health. Vol. II. New Delhi: The Manager of Publication; 1996.

p. 1-73, A-54.

Chauduri SK. Concise Medical Physiology. 2nd ed. Calcutta: New

Central Book Agency (P) Limited; 1996. p. 503.

Uno H, Stenn KS, Massenger AG, Baden HP. Quantitative models for

the study of hair growth in vivo. Molecular and Structural Biology of

Hair. New York: New York Academy of Science; 1991. p. 642.

Mithal BM, Shah RN. A Hand Book of Cosmetics. 1st ed. Delhi: Vallabh

Prakashan; 2000.

Tortora GJ, Grabowski SR. Principles of Anatomy and Physiology.

th ed. Menlopark, California: Harper Collins Publishers;

p. 129.



How to Cite

Jain, P. K., S. Ak, D. Das, and P. K. Jain. “ALTERNATIVE HERBAL DRUGS USED FOR TREATING HAIR DISEASE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 1, Jan. 2016, pp. 110-2,



Original Article(s)