NEUROPROTECTIVE EFFECT OF SARGASSUM ILICIFOLIUM TURNER C. AGARDH ON ACETYLCHOLINESTERASE ACTIVITY AND ATTENUATION OF SCOPOLAMINE-INDUCED AMNESIA IN RODENTS

Authors

  • Sumithra M
  • Arunachalam G
  • Arunachalam G
  • Chitra V
  • Arunachalam G
  • Gowri K
  • Chitra V
  • Chitra V
  • Gowri K
  • Gowri K

Abstract

ABSTRACT
Objective: In day to day life, occupational stress is responsible for oxidative stress by altering sleep cycle. Scopolamine induction of amnesia correlates
to stress-induced amnesia in youngsters. Hence, the present study was aimed to investigate the anti-amnesic effect of ethanolic extract and ethyl
acetate fraction of Sargassum ilicifolium Turner (C. Agardh) against scopolamine.
Methods: In this study, seven groups of animals were used and scopolamine (0.4 mg/kg b.wt/intraperitoneally) was administered to all groups except
positive control to induce memory loss. Elevated plus maze, Morris water maze served as an exteroceptive behavioral model in testing memory in
young rats. Brain acetylcholinesterase, a biomarker enzyme was estimated. Finally histopathology of cerebral cortex was performed.
Results: The extract and fraction treated group showed an interesting result in memory scores, and the significant enzyme inhibition might be
responsible to attenuate acetylcholine in cholinergic neurons to enhance memory. Finally, histopathology of cerebral cortex proved the neuroprotective
effect of S. ilicifolium. All the results were statistically significant.
Conclusion: Neuroprotective role of S. ilicifolium Turner C.Agardh was highlighted well in this study and it will be interesting infuture to dissect out
the kinetics of individual components in the fraction and to strengthen the phytomolecule role by insilico studies.
Keywords: Learning, Memory, Acetylcholinesterase, Sargassum ilicifolium Turner (C. Agardh).

References

REFERENCES

Qui C, Kivipelto M, von Strauss E. E. Epidemology of Alzheimer’s

disease: Occurence, determinants and stragies toward intervention. Clin

Neurosci 2009;11(2):111-28.

Wolf OT, Kirschbaum C. Endogenous estradiol and testosterone levels

are associated with cognitive performance in older women and men.

Horm Behav 2002;41(3):259-66.

Borgesan F. The Marine algae of Danish West Indies 3-Parts.

Amsterdam: Koeltz Scientific Publisher; 1985.

Raven Peter H, Evert R, Susan EE. (n.d.). Biology of Plants. New York:

W. H. Freeman and Company; 2004.

Parle M, Dhingra D, Kulkarni SK. Improvement of mouse memory by

Myristican fragrans seeds. J Med Food 2004;7(2)157-161.

Morris R. Developments of a water-maze procedure for studying spatial

learning in the rat. J Neurosci Methods 1984;11:47-60.

Ellman G, Coutney K, Andres V, Featherstone R. A new and rapid

calorimetric determination of acetyl cholinesterease activity. Biochem

Pharmacol 1961;7(2):88-95.

Goverdhan P, Sravanthi A, Mamatha T. Neuroprotective effects of

meloxicam and selegiline in scopolamine-induced cognitive impairment

and oxidative stress. Int J Alzheimers Dis 2012;2012:974013.

Kopelmann MD, Corn TH. Cholinergic blockade as a model of

cholinergic depletion. A comparison of the memory deficits with those

of Alzheimer-type dementia and the alcoholic Korsakoff syndrome.

Brain 1998;111:1079-110.

De A, Furlan C. The effect of ascorbic acid and oxiracetam on

scopolamine induced amnesia in a habituation test in aged mice.

Neurobiol Learn Memory 1995;64(2):119-24.

D’Hooge R, Dedeyn P. Applications of teh morris water maze in the

study of learning and memory. Brian Res Rev 2001;36(1):60-90.

Gage F, Bjorklund A. Cholinergic septal grafts in to the hippocampal

formation improve spatial learning and memory in aged rats by an

atropine-sensitive mechainism. J Neurosci 1986;6(10)2837-47.

Tranum K, Pathak CM, Pandhi P, Khanduja KL. Effect of green tea

extract in learning, memory, behaviour and acetylcholinesterase activity

in young and old male rats. Brian Cognition 2008;67:25-30.

Ghelardini C, Galeotti N, Barbalomni A, Furukawa S. Memory

facilitation and stimulation of endogenous nerve growth factor

synthesized by acetyl choline releaser PG-9. Jpn J Pharmacol

;78:245-51.

Published

2016-03-01

How to Cite

M, S., A. G, A. G, C. V, A. G, G. K, C. V, C. V, G. K, and G. K. “NEUROPROTECTIVE EFFECT OF SARGASSUM ILICIFOLIUM TURNER C. AGARDH ON ACETYLCHOLINESTERASE ACTIVITY AND ATTENUATION OF SCOPOLAMINE-INDUCED AMNESIA IN RODENTS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 2, Mar. 2016, pp. 93-96, https://innovareacademics.in/journals/index.php/ajpcr/article/view/9737.

Issue

Section

Original Article(s)

Most read articles by the same author(s)

1 2 > >>