• Srinivas Hebbar Shree Devi College of Pharmacy, Mangalore, Rajiv Gandhi University of Health Sciences, Bangalore
  • Akhilesh Dubey Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangaluru-575018, India
  • Ravi G. S. Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangaluru-575018, India
  • Shanon Ben Mascarenhas Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Deralakatte, Mangaluru-575018, India


Objective: The aim of the present study was to prepare hydrogel matrix tablets for controlled release of an anti-asthma drug (Montelukast sodium) by modifying the applications of chitosan by crosslinking it with the different cross linking agent.

Methods: The hydrogels were prepared by crosslinking chitosan using three different crosslinking agents namely, anhydrous dextrose (DXT), sodium tripolyphosphate (TPP) and glutaraldehyde (GL). Formulations were prepared by direct compression method and pre and post compression parameters were evaluated.

Results: FTIR (Fourier transform infrared spectroscopy) studies of tablet formulation indicated that there is no drug-excipient interaction in the prepared formulations. The matrix tablets were capable of releasing the drug for 11 h depending upon the formulation variables. The tablets prepared by plain chitosan discharged the drug quickly, while those prepared by using GL crosslinked-hydrogel released the drug more slowly in a controlled manner. In general, the order of drug release from the crosslinked hydrogel matrix tablets on the basis of crosslinking agents, was found to be DXT>TPP>GL. The type of cross-linking agents affected the drug release rate and in the case of the tablets prepared with CHTPP (95 % to 83 %) it was slower than for the tablets prepared with CHDX (96 % to 88 %) at the end of 11th h. CHGL tablets showed more prolonged drug release profiles (86 % to 74 %) as compared to CHDX and CHTPP at the end of 11th h. In vitro release data was fitted into various release kinetic models to study the release mechanism and showed zero order kinetics and n†value were found to be less than 0.5 indicated the release mechanism followed fickian diffusion due to swelling of gel matrix and high solubility of montelukast sodium.

Conclusion: From the experimental results it can be concluded that hydrogels of chitosan were successfully prepared by using DXT, TPP and GL with different concentration.

Keywords: Montelukast sodium, Chemical cross linking, Chitosan, In vitro release


1. Vijay SJ, Himmath S, Santhosh KS. Recent trends on hydrogel in the human body. Int J Res Pharm Biomed Sci 2011;2:442-7.
2. Chauhan S, Harikumar SL, Kanupriya. Hydrogels: a smart drug delivery system. Int J Res Pharm Chem 2012;2:603-14.
3. Zarzyck R, Modrzejewska Z, Nawrotek K. Drug release from hydrogel matrices. Ecol Chem Eng 2010;17:117-36.
4. Ray M, Pal K, Anis A, Banthia AK. Development and characterization of chitosan-based polymeric hydrogel membrane. Des Monomers Polym 2010;13:193-206.
5. Narasimha SM, Ragavendra VK, Ramarao N, Muchandi IS. Cross-linked chitosan hydrogel matrix tablets for controlled release of gabapentin. Farmacia 2012;60:272-86.
6. Abdul HM, Lokeswara VB, Narottam P, Srinivasa RA. Formulation and evaluation of sustained release matrix tablets of montelukast sodium. Int J Pharm 2012;2:574-82.
7. Ragavendra RNG, Abdul MH, Mansoori W, Munde MR, Shrishail MG. Development and evaluation of a tablets-filled-capsule system for chronotherapeutic delivery of montelukast sodium. Int J Pharm Tech 2011;3:1702-21.
8. Thawatchai P, Juree C, Jongjan M. Characterization and in vitro drug release of a chitosan-magnessium stearate monolithic matrix system. Asian J Pharm Sci 2009;4:265-76.
9. Krunal PM, Patel MB, Anil B. Design development and evaluation of modified release tablets of montelukast sodium using ethyl cellulose and tragacanth. Int Res J Pharm 2011;2:175-8.
10. Hima PV, Akshay PR, Janki BB. Formulation, development and evaluation of doxophylline sustained release matrix tablet. Int Res J Pharm 2011;2:204-7.
11. Rahul S, Premchandani TA, Saxena RC. Formulation and evaluation of buccoadhesive tablets of montelukast sodium. Asian J Pharm Clin Res 2011;4:65-8.
12. Indian Pharmacopoeia published by the Controller of Publication. New Delhi; 2007. p. 242-2.
13. Naresh V, Shivkumar G. Interpenetrating network super porous hydrogels for gastro retentive application preparation, swelling and mechanical properties. Turk J Pharm Sci 2012;9:127-38.
14. Pavitra TK, Harshitha R, Paneer K, Renuka S, Prakash RB, Narendra C. Formulation and evaluation of hydrogel based oral controlled drug delivery system for the antihypertensive drug. J Pharm Sci Technol 2010;2:276-83.
15. Shruthi K, Archana C, Kishore C, Latha K, Thahera D. Preparation and evaluation of montelukast sodium chewable tablets using modified karaya gum. Pharm Sinica 2013;4:125-35.
16. Saleem MA, Azaruddin SM, Sadat A, Patil CC. Studies on different chitosan polyelectrolyte complex hydrogels for modified release of diltiazem hydroclhloride. Int J Pharm Sci 2010;2:64-7.
17. Chinedum E, Andrade C, Marcia C, Barretto B, Damian C. Ionically cross-linked chitosan/ tripolyphosphate micro-particles for the controlled delivery of pyrimethamine. Ibosina J Med Biomed Sci 2011;3:77-88.
18. Swapna K, Aparna C, Prathima S. Formulation and evaluation of montelukast sodium and levocetirizine dihydrochloride sublingual tablets. Asian J Pharm Clin Res 2015;8:171-5.
19. Anal AK, Stevens WF. Chitosan-alginate multilayer beads for controlled release of ampicillin. Int J Pharm 2005;290:45-54.
20. Risbud MV, Bhonde RR. Polyacrylamide-chitosan hydrogels: in vitro biocompatibility and sustained antibiotic release studies. Drug Delivery 2000;7:69-75.
21. Ritger PL, Peppa NA. A simple equation of solute release 11 fickian and anomalous from swellable devices. J Controlled Release 1987;5:37-42.
466 Views | 784 Downloads
How to Cite
Hebbar, S., Dubey, A., S., R. G., & Mascarenhas, S. B. (2017). STUDIES ON CROSS-LINKED CHITOSAN HYDROGEL FOR MATRIX TABLETS OF MONTELUKAST SODIUM. International Journal of Applied Pharmaceutics, 9(4), 22-29.
Original Article(s)