Design and Evaluation of Buccal Patches Containing Combination of Hydrochlorothiazide and Atenolol


Akhilesh Dubey

Abstract


Purpose: Buccal patch is a non-dissolving thin matrix modified release dosage form composed of one or more polymer films or layers containing the drug and/or other excipients. It was developed to administer the patients who are unconscious, less co-operative and also to prevent accidental swallowing of drugs. Moreover, rapid onset of action can be achieved and the formulation can be removed if therapy is required to be discontinued. Methods: The mucoadhesive buccal patches of Hydrochlorothiazide and Atenolol were prepared by solvent casting technique using various concentrations of sodium alginate, hydroxyl propyl methyl cellulose, carbopol 934P and sodium carboxy methyl cellulose polymer and poly vinyl alcohol as backing layer. The formulated patches were evaluated for their physicochemical parameters like thickness, weight variation, surface pH, content uniformity, folding endurance, swelling percentage studies and tensile strength, in vitro and ex vivo drug permeation. Results: The IR spectra showed no interaction between drug and polymer. Physicochemical characteristics of all the samples were found to be satisfactory. Swelling of the films increased with increasing content of polymers. Bioadhesive force, tensile strength, percentage elongation and disintegration time increased with higher proportions of HPMC. The films were exhibited sustained release for more than 6 h. The in vitro release data were fit to different equation and kinetic models to explain release profiles and it was found to be combination of diffusion and erosion mechanism. The best mucoadhesive performance and matrix controlled release was exhibited by the formulation FC. Conclusion: The formulation of Hydrochlorothiazide and Atenolol mucoadhesive buccal patch was found to be perfect and ready for therapeutic use.


Keywords


Buccal mucosa, solvent casting method, Hydroxy propyl methyl cellulose (HPMC) Hydrochlorothiazide, Atenolol, Mucoadhesive buccal patches

References


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