PROTOTYPE SELF EMULSIFYING SYSTEM OF ETRAVIRINE: DESIGN, FORMULATION AND IN VITRO EVALUATION


G. B. Preethi, H. N. Shivakumar, M Ravi Kumar, N Sweta

Abstract


Objective: Lipid-based formulations have gained much attention, particularly on self-emulsifying drug delivery systems (SEDDS), to improve the oral bioavailability of lipophilic drugs. In the present study, an attempt was made to develop and evaluate prototype SEDDS of poorly soluble antiviral BCS class IV drug etravirine.

Methods: Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the screening, gelucire 44/14, as the oil, labrasol as a surfactant and transcutol HP as the co-surfactant were selected. SEDDS with drug etravirine was formulated and evaluated for emulsifying ability, dilution potential and microscopic properties. The emulsion area for each of the combination of oil and surfactant co-surfactant mixture (Smix) was determined by the construction of pseudo-ternary phase diagrams.

Results: The optimized formulation with oil (gelucire 44/14) and Smix (labrasol: transcutol HP, 6:1) in a ratio of 2:8 exhibited a rapid emulsification rate and a good polydispersibility index of 0.103±0.012 indicating uniformity of the formed droplets. The size of the droplets was determined by zetasizer and was found to be in 200 nm range. The drug release from the final formulation after 2hr was found to be 41.15%±0.5 compared to 19.3%±3.8 of pure drug indicating enhanced dissolution profile of the drug.

Conclusion: In vitro study illustrated enhanced dissolution rate of formulated prototype SEDDS of BCS class IV drug etravirine for oral delivery.


Keywords


Etravirine, Self emulsifying system, Gelucire44/14, BCS class IV, Antiretroviral

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About this article

Title

PROTOTYPE SELF EMULSIFYING SYSTEM OF ETRAVIRINE: DESIGN, FORMULATION AND IN VITRO EVALUATION

Keywords

Etravirine, Self emulsifying system, Gelucire44/14, BCS class IV, Antiretroviral

DOI

10.22159/ijap.2018v10i2.22714

Date

07-03-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 2 (Mar-Apr), 2018 Page: 13-19

Online ISSN

0975-7058

Authors & Affiliations

G. B. Preethi
Department of Pharmaceutics, KLEU College of Pharmacy, BENGALURU
India

H. N. Shivakumar
Department of Pharmaceutics, KLEU College of Pharmacy, BENGALURU
India

M Ravi Kumar
Geethanjali College of Pharmacy, Cheeryal (V), Keesara (M), RR District, Telangana
India

N Sweta
Department of Pharmaceutics, KLEU College of Pharmacy, BENGALURU


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