ANTIBACTERIAL EFFECT OF FLAVONOIDS FROM PROPOLIS PRODUCED BY TRIGONA ON ATPASE ACTIVITY OF STREPTOCOCCUS MUTANS


Dian Erlianda, Mochamad Fahlevi Rizal, Sarworini B. Budiardjo

Abstract


Objective: Caries are a major problem related to oral health among children. As it is an infectious disease, bacteria, especially Streptococcus mutans, play an important role in caries. Flavonoids have been known to have antibacterial effects, and ethanol, even at very low concentrations, reportedly has antibacterial effects and is widely used as a basic ingredient in drugs.

Aim: This study aims to analyze the antibacterial effects of different concentrations of propolis flavonoids and ethanol against S. mutans ATPase activity.

Methods: S. mutans cells were exposed to 0.5%, 0.25%, 0.1%, 0.075%, and 0.05% propolis flavonoids and then incubated in an anaerobic atmosphere for 48 h. The ATPase activity in these cells was then tested using a colorimetric assay.

Results: No significant difference was found in the average ATPase activity of S. mutans after treatment with various concentrations of propolis flavonoids and ethanol.

Conclusions: Thus, 0.5%, 0.25%, 0.1%, 0.075%, and 0.05% propolis flavonoids and 10% ethanol had similar effects against S. mutans ATPase activity. Further studies are necessary to evaluate the efficacy of flavonoids from Trigona spp. propolis.

 


Keywords


flavonoids, propolis, antibacterial, ATPase activity, Streptococcus mutans.

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About this article

Title

ANTIBACTERIAL EFFECT OF FLAVONOIDS FROM PROPOLIS PRODUCED BY TRIGONA ON ATPASE ACTIVITY OF STREPTOCOCCUS MUTANS

Keywords

flavonoids, propolis, antibacterial, ATPase activity, Streptococcus mutans.

DOI

10.22159/ijap.2017.v9s2.02

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue 2 (Dec.), 2017 Page: 6-9

Online ISSN

0975-7058

Statistics

155 Views | 116 Downloads

Authors & Affiliations

Dian Erlianda
Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Indonesia

Mochamad Fahlevi Rizal
Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Sarworini B. Budiardjo
Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia


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