FORMULATION AND IN VITRO EVALUATION OF ORAL DISINTEGRATING TABLETS OF AMLODIPINE BESYLATE
DOI:
https://doi.org/10.22159/ijap.2019v11i1.28457Keywords:
Oral disintegrating tablets, Amlodipine besylate, ODTs, Crospovidone, Croscarmellose sodiumAbstract
Objective: The present investigation was undertaken with an objective of formulating oral disintegrating tablets of amlodipine besylate to enhance convenience and compliance of the elderly and pediatric patients for better therapeutic efficacy.
Methods: The tablets were prepared by using direct compression method and evaluated for weight variation, hardness, friability, wetting time, disintegration time and in vitro drug release study. Prepared tablets were evaluated for compatibility by Fourier transform infrared spectroscopy.
Results: Fourier transform infrared spectroscopy studies revealed that there was no physicochemical interaction between amlodipine besylate and other excipients. All the tablets hardness was found to be around 3.5 kg/cm2 and friability of all the formulations was less than 1%, Drug content in all the formulations was found in the range of 97.05% to 99.13%.
Conclusion: The study clearly indicated that the type and concentration of superdisintegrants plays an important role in disintegration and dissolution of drug from oral disintegrating tablets. Among all the formulations, the maximum percentage of drug release and less disintegration time was found in F9 formulation containing 4% of crospovidone.Â
Downloads
References
Behin SR, Punitha ISR, Suraj D. Formulation and characterization of fast disintegrating tablets of amlodipine using superdisintegrants. J Appl Pharm Sci 2012;2:118-23.
Mohanachandran PS, Krishna Mohan PR, Saju F, Bani KB, Babu B, Shalina KK. Formulation and evaluation of mouth dispersible tablets of amlodipine besylate. Int J Appl Pharma 2010:2:1-6.
Vineet B, Mayank B, Sharma PK. Formulation and evaluation of fast dissolving tablets of amlopdipine besylate using different superdisintegrants and camphor as a sublimating agent. Am Eur J Sci Res 2010:5:264-9.
Shelke PV, Dumbare AS, Gandhave MV, Jadhav SL, Sonawane, Gaikwad DD. Formulation and evaluation of rapidly disintegrating film of amlodipine besylate. J Drug Delivery Ther 2012;2:72-5.
Muhammad AS, Syed FA, Marium FK, Sofia A, Iqbal A. Formulations of amlodipine: a review. J Pharmacetics 2016;1-11. Doi: 10.1155/2016/8961621.
Deepthi PR, Satish KK. Formulation and evaluation of amlodipine besylate oral thin films. Int J Pharma Sci Res 2016;7:199-205.
Shireen B, Syed AAB, Shazia F. Formulation and invitro evaluation of mouth dissolving tablets of amlodipine and rosuvastatin. Int J Curr Pharm Res 2015;7:88-91.
Nirav VP, Sachin C, Chintan Aundhia, Seth AK. Formulation and evaluation of amlodipine besylate orally disintegrating tablet. Indo Am J Pharma Res 2011;2:146-52.
Vijaya VCS, Vidyavathi M. Preparation and in vitro characterisation of bosentan monohydrate mucoadhesive microspheres. Eur J Pharma Med Res 2016;3:340-50.
Pratik SD, Sushma V, Puja S. Fast dissolving tablet using solid dispersion technique: a review. Int J Curr Pharm Res 2017;9:1-4.
Harekrishna R, Kirti RP, Sisir N, Sanjay KP, Debendra KM. Design of fast dissolving amlodipine besylate tablet formulations. Asian J Pharm 2012;6:51-9.
Asmaa AB. Formulationn optimization and evaluation of simvastatin rapidly dissolving tablets. Int J Appl Pharma 2018;10:270-3.
Sudhir B, Vinay J, Jar RC, Ashish M, Suman J. Formulation and evaluation of fast dissolving tablets of aceclofenac. Int J Drug Delivery 2010;2:93-7.
Kuchekar B, Badhan A, Mahajan H. Mouth dissolving tablets of salbutamol sulphate: a novel drug delivery system. Indian Drugs 2004;41:592–8.
Ashwini R Madgulkar, Bhalekar, Rahul RP. Formulation design and optimization of novel taste masked mouth-dissolving tablets of tramadol having adequate mechanical strength. AAPS PharmSciTech 2009;10:574-81.
Rashmi D, Ashish P, Sanjay N. Formulation and evaluation of mouth dissolving tablet containing amlodipine besylate solid dispersion. Int J Chem Tech Res 2010;2:706-15.
