FORMULATION AND IN VITRO EVALUATION OF MATRIX TABLETS OF METOCLOPRAMIDE HYDROCHLORIDE
DOI:
https://doi.org/10.22159/ijap.2019v11i2.30506Keywords:
Matrix tablets, Metoclopramide hydrochloride, Xanthan gumAbstract
Objective: The purpose of present study was to formulate oral sustained release matrix tablet of metoclopramide hydrochloride and to evaluate the effect of varying concentrations of hydrophobic and hydrophilic polymers on drug release.
Methods: Drug–excipients compatibility studies were carried out by using Fourier transform infrared spectroscopy (FTIR). The matrix tablets were prepared by direct compression technique using Xanthan gum and ethyl cellulose alone and in combination as release retardant. Dicalcium phosphate was used as diluent. The prepared matrix tablets were evaluated for their physicochemical parameters such as weight variation, hardness, friability, content uniformity and in vitro drug release studies were performed using USP-type II (paddle) dissolution apparatus.
Results: Pre and post compression parameters were evaluated and all the parameters were found within the limit. The matrix tablets prepared with xanthan gum and combination of xanthan gum and ethyl cellulose were retarded the drug release upto 12 h. Ethyl cellulose alone could not control the drug release for 12 h. The Formulation with drug to xanthan gum (1:1.5), released 97.62 % of drug in 12 h. The kinetic treatment showed that the release of drug follows zero order kinetics (R 2=0.985). Korsmeyer and Peppas equation values of n were found to be in the range of 0.40-0.56, indicating that the drug release mechanism was diffusion.
Conclusion: Matrix tablet is the simple, efficient and economic method to sustain the release of metoclopramide to prevent extrapyramidal side effects.
Downloads
References
Patel MH, Ashok KP, Suresh K, Someshwara RB. Design and evaluation of controlled release matrix tablets of metoclopramide hydrochloride using hydrophilic polymers. Int J Curr Pharma Res 2012;4:64-9.
Paloma F, Cristiana P, Jose LL, Gloria F. In vitro release of metoclopramide from hydrophobic matrix tablets. Influence of hydrodynamic conditions on kinetic release parameters. Chem Pharm Bull 2001;49:1267-71.
Mannujan N, Saiful MD, Fatima N, Syed SH. Development of sustained-release preparations of metoclopramide hydrochloride based on the fatty matrix. Dhaka Univer J Pharm Sci 2012;11:129-36.
Neha SL, Neelam S, Yasir M. Sstained release solid dispersion of metoclopramide hydrochloride: formulation, evaluation, and pharmacokinetic studies. J Appl Pharma Sci 2015;5:55-65.
Sayed AR, Gamal MM, Mahmuod EB. Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets. Saudi Pharm J 2009;17:283-8.
Sateesh KV, Prabhakar RV. Colon specific controlled release matrix tablets of flurbiprofen: development and characterization. Asian J Pharm Clini Res 2012;5:92-6.
Ranjith PS, Ratna KT, Satyajit P. Formualtion development and evaluation of sustained release ibuprofen tablets with acrylic polymers and HPMC. Int J Pharma Pharma Sci 2016;8:131-5.
Sabyasachi M, Santanu K, Somasree R, Biswanath S. Development and evaluation of xanthan gum facilitated ethyl cellulose microsponges for controlled percutaneous delivery of diclofenac sodium. Acta Pharm 2011;61:257-70.
Geeta MP, Madhabhai MP. Compressed matrix dual–component vaginal drug delivery system containing metoclopramide hydrochloride. Acta Pharm 2009;59:273-88.
Raghavendra Rao NG, Prasanna KR, Sanjeev NB. Review on matrix tablets as sustained release. Int J Pharma Res Alli Sci 2013;2:1-17.
Wadher KJ, Ghodasare Ch and Umekar MJ. Formulation and evaluation of controlled release matrix tablets using eudragit RSPO and gum copal. Int J Pharm and chemical Res 2017; 3: 1-7.
Jaya S and Amala V. Formulation and invitro evaluation of oral disintegrating tablets of amlodipine besylate. Int J Appli Pharmaceutics 2019; 11:49-54
Jaya S, Chowdary KPR and Rajeswara RP. Effect of superdisintegrants and solubilizers on the disoolution rate and dissolution efficiency of ritonavir. Int Res J Pharm Appl Sci 2012; 2: 224-9.
Jaya S, Chowdary KPR and Rajeswara RP. Enhancement of dissolution rate and formulation development of ritonavir tablets by solid dispersion technologies. Int J Pharma Therape 2013; 4: 51-8.
Chang R, Robinson JR. Sustained release from tablets and particles through coating In: H.A. Libreman, L. Lachman and J.B. Schwart (Eds), Pharmaceutical dosage forms: Tablets, 2 nd Edn. Vol.3, Marcel Dekker, 1990.199-302.
Suvakanta D, Narasimha MP, Lilakanta n and Prasanta C. Kinetic modeling on drug release from controlled drug delivery systems. Acta Palaniae Pharm Drug Res 2010; 67:217-23.
