• Resmi Mustarichie Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
  • Dolih - Gozali Department of Pharmaceutics, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia



Alpha arbutin, Formulation, Cream, Polyacrylate, Cold process


Objective: The objective of this research was to formulate and evaluate alpha arbutin skin lightening cream using polyacrylate base by cold process.

Methods: Five formulas of alpha arbutin skin lightening cream were prepared with Polyacrylate Base with different polyacrylate concentrations as a cream base for each formula. The various concentrations of polyacrylate (2, 3, 4, 5, and 6%) was used as a cream base. The resulting preparation was then examined and observed for consistency, color, odor, and stability for 28 d of storage.

Results: The phase separation test results stated that the five cream formulas did not experience phase separation in 2500, 3000, and 3750 rpm centrifugations so that it could be concluded that the five cream formulas were stable in storage at room temperature for at least 12 mo. From the physical evaluation of cream preparations, it was found that the cream formula with 6% polyacrylate concentration gave the best stability results. Cream safety testing results stated that the cream did not irritate the skin of the wearer.

Conclusion: The results obtained in this research work clearly indicated alpha arbutin cream can be formulated using polyacrylate as a cream base, and in its manufacture, it can be carried out with a cold process.


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How to Cite

Mustarichie, R., & Gozali, D. .-. (2019). FORMULATION AND EVALUATION OF ALPHA ARBUTIN SKIN LIGHTENING CREAM USING POLYACRYLATE BASE BY COLD PROCESS. International Journal of Applied Pharmaceutics, 11(1), 100–105.



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