FORMULATION, STANDARDIZATION AND EVALUATION OF POLYHERBAL DISPERSIBLE TABLET


Harikesh Maurya, Tirath Kumar

Abstract


Objective: The study was designed as formulation, standardization and evaluation of polyherbal dispersible tablets prepared for the management of kidney disorders. In favor of improving the patients complain about simplicity in administration through swallow dispersible tablets.

Methods: Dispersible tablets were prepared using aqueous root extract powder of the selected plant viz. A. officinalisB. diffusaC. papaya, C. fistula, C. intybus, F. hispida, F. indica, C. nurvala, S. virgaurea, and V. negundo with the help of superdisintegrant addition technique using crospovidone, sodium starch glycolate and croscarmellose sodium in different percentage. Evaluation assessments such as the substantial test, weight variation, hardness, friability, content uniformity, disintegration, in-vitro dispersion, stability study and IR compatibility were carried out.

Results: Micromeritics of extracts powder were determined for all formulation, which signifying good flow properties. The substantial examination was established, which comply with official requirements for uniformity test, and the drug content was close to 100% in all formulations. Disintegration time was observed for all formulation in which the polyherbal formulation-3 (PHF-3) showing 1.10±0.10 min; during in-vitro dispersion time, all formulation showed appropriate dispersion in which the PHF-3 captivating 2.00±0.45 min only. The IR compatibility shows none chemical interaction between the extracts and excipients.

Conclusion: The PHF-3 showed satisfactory disintegration and in-vitro dispersion time due to crospovidone and reported as the best formulation. The stability study and IR compatibility validate the PHF may represent new easily swallow dispersible tablet that may enhance drug permeability and advance bioavailability for nephrotic patients

Keywords


Polyherbal dispersible tablet, Micromeritics, Dispersion time, Superdisintegrants, Crospovidone, IR compatibility

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