The EFFECT OF POLYMERIC BLEND ON EX-VIVO PERMEATION STUDIES OF ACECLOFENAC LOADED FILM FORMING GEL
Ex vivo permeation studies of aceclofenac loaded film forming gel
Objective: To date, film-forming systems have been intensively investigated for transdermal drug delivery. Film forming systems offers various advantages compared over conventional transdermal drug delivery systems. The objective of the present study was to study the effect of polymeric blend on ex-vivo permeation studies of topical film-forming gel of aceclofenac. Methods: Film-forming gels were prepared by using Hydroxy propyl methyl cellulose and Eudragit polymeric blend in varied concentrations, polyethylene glycol 400 as plasticizer, ethanol as solvent and tween 80 as penetration enhancer. The prepared film-forming gels were evaluated and the influence of the concentration and ratio of polymeric blends used plasticizer and ethanol were investigated. Result: All the prepared film-forming gels showed satisfactory properties regarding homogeneity, compatibility, viscosity and pH value. Variation in the concentration of polymers showed a variable effect on drug permeation rate from film-forming gels. Conclusion: Film-forming gels of aceclofenac with sustained release profile were successfully developed and may provide a promising effective formulation which may improve patient’s compliance.
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