EFFECTS OF NANOCURCUMIN IN RATS WITH DIABETES INDUCED WITH STREPTOZOTOCIN AND NICOTINAMIDE: MRNA EXPRESSION OF B-TYPE NATRIURETIC PEPTIDE

  • Maryam Ulfa Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia.
  • Dyah Suci Handayani Biomedical Science Postgraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia.
  • Hotlina Nainggolan Biomedical Science Postgraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia.
  • Wawaimuli Arozal Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia.

Abstract

Objective: This study aimed to determine the effects of nanocurcumin on cardiomyopathy, assessed by the expression of B-type natriuretic peptide
(BNP) mRNA in heart tissue.
Methods: Type 2 diabetic rats were induced with streptozotocin and nicotinamide. Nanocurcumin was orally administered (100 mg/kg/day)
for 30 days. BNP-45 mRNA expression in the heart tissue was measured using quantitative reverse transcription-polymerase chain reaction and
calculated using the Livak method.
Results: BNP-45 levels increased significantly (p<0.05) in diabetic rats compared with the normal group. Nanocurcumin treatment at a dose of
100 mg/kg for 30 days significantly decreased BNP-45 expression levels (p<0.05) compared with diabetic rats without treatment.
Conclusion: Nanocurcumin may be beneficial in inhibiting the progression of diabetic cardiomyopathy by suppressing the expression of BNP-45.

Keywords: B-type natriuretic peptide-45, Nanocurcumin, Nicotinamide, Streptozotocin.

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Ulfa, M., Handayani, D. S., Nainggolan, H., & Arozal, W. (2018). EFFECTS OF NANOCURCUMIN IN RATS WITH DIABETES INDUCED WITH STREPTOZOTOCIN AND NICOTINAMIDE: MRNA EXPRESSION OF B-TYPE NATRIURETIC PEPTIDE. International Journal of Applied Pharmaceutics, 10(1), 175-177. https://doi.org/10.22159/ijap.2018.v10s1.38
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