SYNTHESIS AND ANALYSIS OF ZINC METHIONINE, ZINC GLYCINE, COPPER LEUCINE, AND COPPER GLYCINE COMPLEXES USING ATOMIC ABSORPTION SPECTROPHOTOMETRY

  • Sekar Alinda Nastiti Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
  • Harmita . Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.
  • Catur Jatmika Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.

Abstract

Objective: The aim of this study was to perform metal-amino acid synthesis and to analyze the free and bonded mineral concentrations.
Methods: In this study, the synthesis of amino acid metal complexes was carried out by reacting free metal ions, derived from a water-soluble metal
salt, with amino acids in a 1:2 molar ratio.
Results: The respective yields of this synthesis process were 95.38%, 95.95%, 76.31%, and 93.91% for zinc (Zn)-methionine (Zn(Met)2), Zn-glycine
(Zn(gli)2), copper-leucine (Cu(leu)2), and Cu-glycine (Cu(gli)2) complexes, respectively. The metal-amino acid complexes were then separated using
column chromatography and further analyzed by atomic absorption spectrophotometry (AAS). The bonded metal concentrations of the Zn(Met)2,
Zn(gli)2, Cu(leu)2, and Cu(gli)2 complexes were 189.32 mg/g, 353.78 mg/g, 180.89 mg/g, and 275.11 mg/g, respectively. The free metal concentrations
of the Zn(Met)2, Zn(gli)2, Cu(leu)2, and Cu(gli)2 complexes were 13.57 mg/g, 12.92 mg/g, 0.19 mg/g, and 2.12 mg/g, respectively.
Conclusion: In this study, Zn(Met)2, Zn(gli)2, Cu(leu)2, and Cu(gli)2 complexes were successfully formed and analyzed. The mineral concentration in
each complex differed depending on the type of mineral and ligand.

Keywords: Amino acid complex, Atomic absorption spectrophotometry, Concentration, Metal.

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How to Cite
Nastiti, S. A., ., H., & Jatmika, C. (2018). SYNTHESIS AND ANALYSIS OF ZINC METHIONINE, ZINC GLYCINE, COPPER LEUCINE, AND COPPER GLYCINE COMPLEXES USING ATOMIC ABSORPTION SPECTROPHOTOMETRY. International Journal of Applied Pharmaceutics, 10(1), 388-391. https://doi.org/10.22159/ijap.2018.v10s1.86
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