ANALYSIS OF BISPHENOL A IN INDONESIAN CANNED FOOD BY GAS CHROMATOGRAPHY

Authors

  • Herman Suryadi Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Amiratul Haq Rasyid Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Harmita . Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.

DOI:

https://doi.org/10.22159/ijap.2018.v10s1.05

Keywords:

Bisphenol A, Canned foods, Contamination analysis, Gas chromatography-flame ionization detection, Validation

Abstract

Objective: This study aimed to design and optimize a gas chromatography-flame ionization detection (GC-FID) method to determine the bisphenol A (BPA)
content in Indonesian canned food samples.
Methods: GC with Hewlett-Packard-1 capillary columns (length, 30 m; inside diameter, 0.25 mm; and film thickness, 0.25 μm) was used with a column
temperature of 150°C that was programmed to increase by 10°C/min to 260°C. Injector and detector temperatures were 280 and 300°C, respectively,
the gas flow rate was 1.0 mL/min, and injection volume was 3.0 μL. Three types of canned food samples were prepared by ethyl acetate extraction and
stored under four different conditions (4–8°C, 25–30°C, 40°C for 30 min, and 40°C for 60 min) to determine BPA migration levels.
Results: Method validation (system compatibility, selectivity, calibration curve linearity, accuracy, and precision) was acceptable for BPA
concentrations ranging from 2 to 15 μg/mL, with a coefficient of correlation of 0.99983. The limits of detection and quantitation were 0.287 and
0.956 μg/mL, respectively. Only one canned food sample type (Group A) showed BPA contamination under all storage conditions and exceeded the
recommended guidelines for daily ingestion.
Conclusion: The optimized GC-FID method was selective and relatively sensitive in the detection and quantitation of BPA. Furthermore, higher
storage temperatures and durations increased the level of BPA migration into food.

Downloads

Download data is not yet available.

References

Food and Drug Supervisory Agency of the Republic of Indonesia.

Bisphenol A (BPA) on Food Packaging. Jakarta: Food and Drug

Supervisory Agency of the Republic of Indonesia; 2014.

U.S Department of Health and Human Sciences. NTP-CERHR

Monograph on the Potential Human Reproductive and Developmental

Effects of bisphenol A. North Carolina: US State U.S Department of

Health and Human Sciences; 2008.

Rykowska I, Wasiak W. Properties, threats, and methods of analysis of

bisphenol A and its derivatives. Acta Chromatogr 2006;16:7-27.

Shrinithivihahshini N, Mahamuni D, Praveen N. Bisphenol A migration

study in baby feeding bottles of selected brands available in the Indian

market. Curr Sci 2014;25:1081-4.

Dutta M, Paul G. Bisphenol A dose-and time-dependently induces

oxidative stress in rat liver mitochondria vivo. Asian J Pharm Clin Res

;11:98-105.

Indonesian Ministry of Trade. Indonesian Production and Trade–

Indonesia Technical Requirements Information System (INATRIMS);

Available from: http://www.inatrims.kemendag.go.id/id/product/

detail/produksi-dan-perdagangan-indonesia_925/?market=ar]. [Last

accessed on 2017 Jan 23].

Poole CF. Ionization-based detectors for gas chromatography. J

Chromatogr A 2015;1421:137-53.

Obreshkova D, Tsvetkova DD, Ivanov K. Simultaneous identification

and determination of total content of aminoacids in food supplementstablets

by gas chromatography. Asian J Pharm Clin Res 2012;5:57-68.

Preet R, Gupta RC. Determination of fatty acids in Solanum surattense

burm.F. By using gas chromatography. Asian J Pharm Clin Res

;10:60-2.

Gandjar IG, Rohman A. Chemical Pharmacy Analysis. Yogyakarta:

Pustaka Pelajar; 2007. p. 463-80.

Farajzadeh M, Abbaspour M, Mogaddam M, Ghorbanpour H. Determination

of some synthetic phenolic antioxidants and bisphenol A in honey using

dispersive liquid-liquid microextraction followed by gas chromatograhyflame

ionization detection. Food Anal Methods 2015;8:20135-43.

Zuo Y, Zhu Z. Simultaneous identification and quantification of

-cumylphenol, 2,4-bis-(dimethylbenzyl)phenol and bisphenol A in

prawn Macrobrachium rosenbergii. Chemosphere 2014;107:447-53.

Published

20-12-2018

How to Cite

Suryadi, H., Rasyid, A. H., & ., H. (2018). ANALYSIS OF BISPHENOL A IN INDONESIAN CANNED FOOD BY GAS CHROMATOGRAPHY. International Journal of Applied Pharmaceutics, 10(1), 19–23. https://doi.org/10.22159/ijap.2018.v10s1.05

Issue

Section

Original Article(s)

Most read articles by the same author(s)

1 2 3 > >>