FORMULATION AND EVALUATION OF PRESS COATED TABLETS OF LANSOPRAZOLE
Objective: Lansoprazole an proton pump inhibitor, degrades in acidic environment, hence protection of drug is done by coating the drug with enteric coating polymers. The aim and objective of the present study was to prepare enteric coated delayed release tablets of lansoprazole by using press coating technique.
Methods: Core tablets were prepared by direct compression and evaluated for their physico-chemical properties. Press coated tablets were formulated by using different combinations of ethyl cellulose, HPMC E15 and HPMC K4M as a coating layer. Core and coated tablets were optimized by dissolution studies. Fourier transform infra-red spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies were performed to know the compatibility of drug with various excipients. Surface morphology and uniformity of coat was evaluated by Scanning electron microscopy (SEM). Stability of optimized formulation was evaluated according to ICH guidelines.
Results: Among the various formulations F5 containing ethyl cellulose: HPMC E15 (10:90) and F9 containing ethyl cellulose: HPMC K4M (25:75) were optimized based on the better drug release within 8 h. DSC studies and FTIR studies revealed compatibility of drug with excipients. Obtained SEM photographs of tablets showed that the surface of core tablet is uniformly coated with coat by press coating. Stability studies showed that the formulations were stable.
Conclusion: As a result, delayed release press coated tablets developed in this study delivered lansoprazole in the intestine and protected the drug from degradation.
2. Rathore AS, Jat RC, Sharma N, Tiwari R. An overview-matrix tablet as controlled drug delivery system. Int J Res Dev Pharm Life Sci 2013;2:482-92.
3. Venkateswara RB, Navaneetha K, Rashmitha RB. Tablet coating industrial point view-a comprehension review. IJBPS 2013;3:248-61.
4. Ankit G, Ajay B, Mahesh Kumar K, Neethu K. Tablet coating techniques-concepts and recent trends. Int Res J Pharm 2012;3:50-8.
5. Kamble ND, Chaudhari PS, Oswal RJ, Kshirsagar SS, Antre RV, Wagholi P. Innovations in tablet coating technology-a review. Int J Appl Biol Pharm Technol 2011;2:214-8.
6. Winheuser J Cooper. The pharmaceutics of coating tablets by compression. J Am Pharm Assoc 1956;45:542–5.
7. Bose S, Bogner RH. Solvent less pharmaceutical coating processes: a review. Pharm Dev Technol 2007;12:115–31.
8. Rohit P, Manish J, Bhupendra SC, Sanjay KS. Compression coated tablets as drug delivery system (tablet in tablet): a review. IJPRD 2014;6:21-33.
9. Satani RR, Chotaliya MB, Raval MK, Sheth NR. Review on recent trends in press-coated pulse drug delivery system. Int Bull Drug Res 2014;4:60-91.
10. Sharma GS, Srikanth MV, Uhumwangho MU, Kumar Phani KS, Murthy Ramana KV. Recent trends in pulsatile drug delivery systems-a review. Int J Drug Delivery 2010;2:200–12.
11. Janugade BU, Patil SS, Patil SV, Lade PD. Formulation and evaluation of press coated montelukast sodium tablets for pulsatile drug delivery. IJCRGG 2009;1:690-5.
12. Sunil P, Modasiya MK, Patel VM, Patel AK. Design and development of floating pulsatile drug delivery system using meloxicam. Int J Pharm Res Bio Sci 2012;1:215-35.
13. Sonawane SJ, Chaudhari KP, Jadhao UT, Thakare VM, Tekade BW, Patil VR. Design, development and evaluation of press coated tablets of an antihypertensive drug. Sch Acad J Pharm 2014;3:191-6.
14. Enayatifard R, Saeedi M, Akbari J, Tabatabaee YH. Effect of Hydroxy propyl methylcellulose and ethyl cellulose content on release profile and kinetics diltiazem HCl from matrices. Trop J Pharm Res 2009;8:425-32.
15. Bala SK, Swain SR, Bhanja S, Sudhakar M. Formulation and evaluation of delayed release orally disintegrating tablets of lansoprazole. Indo Am J Pharm Res 2013;3:6436-59.
16. Indira MY, Jitendra KP, Sai KV, Sandeep M, Suresh Babu M, Mallikharjuna Rao P. Design and development of chronopharmaceutical drug delivery of lansoprazole. J Pharm Res 2014;8:123-9.
17. Holman LE, Leuenberger H. The relationship between solid fraction and mechanical properties of compacts–the percolation theory model approach. Int J Pharm 1988;46:35-44.
18. Leuenberger H, Rohera BD, Haas C. Percolation theory–a novel approach to solid dosage form design. Int J Pharm 1987;38:109-15.
19. Pham AT, Lee PI. Probing the mechanisms of drug release from hydroxy propyl methyl cellulose matrices. Pharm Res 1994;11:1379-84.
20. Skoug JW, Mikelsons MV, Vigneron CN, Stemm NL. Qualitative evaluation of the mechanism of release of matrix sustained release dosage forms by measurement of polymer release. J Controlled Release 1993;27:227-45.
21. Gangane PS, Mahajan NM, Danao KR, Pawde GN. Formulation and evaluation of chronomodulated pulsatile therapeutic system for early morning surge in blood pressure. Int J Pharm Pharm Sci 2015;7:337-41.
22. Patel H, Pandey S, Patel V, Shah R, Tiwari S. Pulsatile release of ketoprofen from compression coated tablets using eudragit® polymers. Int J Pharm Pharm Sci 2016;8:224-9.
This work is licensed under a Creative Commons Attribution 4.0 International License.