EFFECT OF CENTELLA ASIATICA L. ON THE NUMBER OF OSTEOCLASTS, OSTEOBLASTS, AND OSTEOCYTES IN THE TIBIAE OF OVARIECTOMIZED RATS

Authors

  • VANISSA KARIS Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia
  • SRI ANGKY SOEKANTO Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia
  • ERIK IDRUS Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia

DOI:

https://doi.org/10.22159/ijap.2019.v11s1.AR171

Keywords:

Centella asiatica, Estrogen, Osteoporosis, Osteocytes, Osteoclasts, Osteoblasts

Abstract

Objective: This study aimed to examine the effectiveness of Centella asiatica L. as a phytoestrogen.
Methods: Therapy using C. asiatica extract at doses of 60 mg/kg body weight, 120 mg/kg BW, and 180 mg/kg BW was administered to ovariectomized
rats for 30 days.
Results: Histological examination using hematoxylin and eosin staining demonstrated an increased number of osteocytes and a decreased number of
osteoclasts, but there was no significant increase in osteoblast numbers.
Conclusion: The administration of the low doses of C. asiatica extract affects the number of osteocytes and osteoclasts but not osteoblasts in
ovariectomized rats.

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Published

05-04-2019

How to Cite

KARIS, V., SOEKANTO, S. A., & IDRUS, E. (2019). EFFECT OF CENTELLA ASIATICA L. ON THE NUMBER OF OSTEOCLASTS, OSTEOBLASTS, AND OSTEOCYTES IN THE TIBIAE OF OVARIECTOMIZED RATS. International Journal of Applied Pharmaceutics, 11(1), 71–74. https://doi.org/10.22159/ijap.2019.v11s1.AR171

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