DIFFERENCE BETWEEN ANTIMICROBIAL EFFECTS OF PAPACARIE AND PAPAIN ON STREPTOCOCCUS MUTANS IN VITRO

  • TITTY SULIANTI Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • NILAKESUMA DJAUHARI Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • BAMBANG NURSASONGKO Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.

Abstract

Objective: The aim is to compare the antimicrobial effects of papain and Papacarie with dilution and diffusion tests.
Methods: There were two treatment groups and one Group control. The treatment group received papain and Papacarie, and the control group
received chlorhexidine, in five liquids with different concentrations of 0.5%, 0.25%, 0.125%, 0.0625%, and 0.03%. The dilution and diffusion tests
were used to determine the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and zone of inhibition for each
treatment material.
Results: MICs of papain and Papacarie were 12.5%, indicating that at a concentration of 12.5%, the material can inhibit the growth of Streptococcus
mutans. Papain does not have an MBC value but the Papacarie has an MBC at 25%, which indicating that at a concentration of 25%, Papacarie has
bactericidal effects on S. mutans. The zone of inhibition of papain was lower than Papacarie.
Conclusion: Based on chemomechanical caries removal materials, the antimicrobial effects of Papacarie were better than those of papain.

Keywords: Chlorhexidine, Minimum bactericidal concentration, Minimum inhibitory concentration, Papacarie®, Papain, Zone of inhibition

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SULIANTI, T., DJAUHARI, N., & NURSASONGKO, B. (2019). DIFFERENCE BETWEEN ANTIMICROBIAL EFFECTS OF PAPACARIE AND PAPAIN ON STREPTOCOCCUS MUTANS IN VITRO. International Journal of Applied Pharmaceutics, 11(1), 79-83. https://doi.org/10.22159/ijap.2019.v11s1.AR186
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