SNEDDS USE OF SIMPLEX LATTICE DESIGN IN DEVELOPMENT OF SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM CONTAINING ROSUVASTATIN CALCIUM

  • Nishant Oza C. U. Shah Uinversity

Abstract

Objective: The aim of present work was enhancing permeability and solubility of rosuvastatin calcium by self nanoemulsifying drug delivery system (SNEDDS) using mixtures of oil, co-solvent, surfactant and co-surfactant.


 


Methods: Screening of surfactants and oil was done by solubility method and pseudo ternary phase diagrams of oil, surfactant/co-surfactant and water were developed using water titration method. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region. A series of SNEDDS formulations were prepared using labrasol/cremophor El with combination of peceol/ethyl oleate by using simplex lattice design. Prepared formulation evaluated for refractive index, turbidimetric, droplet size, zeta potential & polydispersity index, self-emulsification, stability tests, viscosity and in-vitro diffusion studies.


 


Results: The optimal SNEDDS was comprised of 15% oil (peceol : ethyloleate in 1:1 ratio), 50% Labrasol and 35% Cremophor EL. The average globule size of optimized formulation was about 22.95±1.50 nm was found. No significant variations in globule size and rosuvastatin content in SNEDDS were observed after 3 month stability study. In-vitro diffusion studies showed more than 95% drug diffusion within 15 minutes.


Conclusion: The data suggest use of rosuvastatin calcium SNEDDS to provide great potential for delivery and it increase the aqueous solubility, permeability and bioavailability of drug.

Keywords: SNEDDS, Rosuvastatin calcium, Simplex lattice design, Peceol, Ethyl oleate, Labrasol, Cremophore EL.

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Oza, N. (2020). SNEDDS USE OF SIMPLEX LATTICE DESIGN IN DEVELOPMENT OF SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM CONTAINING ROSUVASTATIN CALCIUM. International Journal of Applied Pharmaceutics, 12(3). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/34358
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