• NISHANT OZA C. U. Shah College of Pharmacy and Research, Wadhwan City 363030, Gujarat, India
  • AMI MAKWANA C. U. Shah College of Pharmacy and Research, Wadhwan City 363030, Gujarat, India
  • TUSHAR A. GOHIL Smt. C. V. Gajera Pharmacy Mahila College, Amreli 365601, Gujarat, India



Venlafaxine, organogel,, RSM


Objective: The aim of this study was to develop the oral Venlafaxine HCl controlled release organogel (organogel – CR) by using one factor response surface methodology (RSM).

Methods: In this study, Drug-excipient compatibility was evaluated by FT-IR. A total of 14 experimental runs were carried out employing the detailed conditions designed by single factor completely randomized design based on the response surface methodology was used to check the concentration effect of 12- Hydroxy stearic acid (12- HSA) at different cooling rates on drug release at 10 h (Q10) and after 12 h (Q12). Multiple linear regression analysis, analysis of variance (ANOVA) and graphical representation of the influence factor were performed by using design expert 12. The developed organogel was also evaluated for viscosity, strength, transition temperature, diffusivity and Scanning electron microscopy (SEM). Prepared organogel was filled in the capsule and investigated for weight variation, drug content, erosion of organogel and In-vitro drug release study.

Results: FT-IR results showed that there was no chemical interaction between the drug and excipients. The SEM photograph indicates that the developed organogel was highly viscous with 3D network structure. The experimental confirmation tests showed a correlation between the predicted and experimental responses (R2 = 0.9937 and 0.9709). The results of ANOVA suggested that calculated F values of all dependent variables are greater than tabulated values. The optimal point obtained was located in the valid region and the optimum in-vitro release of predicted batch containing 7.9% concentration of 12-HSA with gradual cooling rate. To validate the evolved mathematical models, a check point was selected and its desirability value was found to be 0.866.

Conclusion: Oral controlled release Venlafaxine HCl organogel fix the problem of repeated dosing and patient noncompliance.


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Andrews JM, Ninan PT, Nemeroff CB. Venlafaxine: a novel antidepressant that has a dual mechanism of action. Depression. 1996;4:48–56.

Olver JS, Burrows GD, Norman TR. Third-generation antidepressants: do they offer advantages over the SSRIs? CNS Drugs. 2001;15:941–54.

Holiday SM, BenÞeld P. Venlafaxine: A review of its pharmacology and therapeutic potential in depression. Drugs. 1995;49:280-94.

Haskins JT, Moyer JA,, Muth EA. Sigg E. Inhibition of noradrenergic neuronal activity by the novel bicyclic compounds, Wy- 45030 and Wy-45881. Soc Neuro sci Abstr. 1984;10:262.

Troy SM, Parker VD, Fruncillo RJ, Chiang ST. The pharmacokinetics of venlafaxine when given in a twice-daily regimen. J Clin Pharmacol. 1995;35:404-9.

Jyoti P. Development and Optimization of Extended-Release Venlafaxine HCl Matrix Tablet. Asian J Pharm Tech Innovation. 3(2):2013;76-80.

Shilpa J, Monika D. Montmorillonite-alginate microspheres as a delivery vehicle for oral extended release of Venlafaxine hydrochloride. J Drug Del Sci Tech. 2016;33:149-56.

Dilip M, Kumbhar VD, Havaldar, Kailas KM, Remeth JD, Vishwajeet SG, Rahul B. Londhe. Formulation and evaluation of sustained release tablets of venlafaxine hydrochloride for the treatment of depressive disorders. Asian J Pharm Res. 2017; 7(1): 8-14.

Jobin J, Kavya G. Organogels: A Versatile drug delivery tool in pharmaceuticals. Research J Pharm and Tech. 2018;11(3):1242-6.

Purohit B, Gupta N, Jain S. Formulation and evaluation of diclofenac sodium organogel. Research J Pharm and Tech. 2013;6(4):375-8

Nithya R, Binita K. Development and characterization of reverse micelle based pluronic lecithin organogel containing imatinib mesylate. Research J Pharm and Tech. 2021;14(3):1209-14.

Abdelmonem, R, Eltahan, M, El-Nabarawi M. Development and evaluation of taste masked oro-disintegrating tablets of itopride hcl using different co-processed excipients: pharmacokinetics study on rabbits. Int J Appl Pharm. 2022 14(3), 69–79.

Carlson E, Chandler W, Galdo I, kudla T. Automated integrated forced degradation and drug-excipients compatibility studies. J Assoc Lab Autom. 2005;10:374-80.

Garg T, Bilandi A, Kapoor B. Oraganogel advanced and novel drug delivery system. Int Res J Pharm. 2011;2(12):15-21.

Fayez SM, Gad S. Formulation and evaluation of etodolac lecithin organogel transdermal delivery systems. Int J Pharm Pharm Sci 2005;7:325-34.

Jayprakash R, Hameed J, Anupriya. An overview of the transdermal delivery system. Asian J Pharm Clin Res 2017;10:36-40.

Sharma G, Devi N, Thakur K. Lanolin-based organogel of salicylic acid: evidences of better dermatokinetic profile in imiquimod-induced keratolytic therapy in BALB/c mice model. Drug Delivery Transl Res 2018;8:398-413.

Vigato AA, Querobino SM, de Faria NC. Synthesis and characterization of nanostructured lipid-poloxamer organogels for enhanced skin local anesthesia. Eur J Pharm Sci 2019;128:270-8.

Vintiloiu A, Leroux JC. Organogels and their use in drug delivery-a review. J Controlled Release 2008;125:179-92.

Indrajeet SP, Omkar AP, Girish CR, Manoj MN. Development and evaluation of telmisartan pulsatile drug delivery by using response surface methodology. Asian J Pharm Res. 2018;8(4):205-14.

Mahesh PG, Jeganath S. Formulation and evaluation of venlafaxine hydrochloride sustained release matrix tablet. Asian Journal of Pharmaceutical and Clinical Research. 2018;11(16):170-4

Upadhyay KK, Tiwari C, Khopade AJ. Sorbitan ester organogels for transdermal delivery of sumatriptan. Drug Dev Ind Pharm 2007;33:617-25.

Alex A, Alexander J, Kristi S. Poly (ethylene glycol) hydrogels formed by thiol-enephoto polymerization for enzyme responsive protein delivery. Biomaterials. 2009;30(30):6048-54.

Swain S, Behera A, Dinda SC, Patra CN, Jammula S, Beg S, Rao ME. Formulation design, optimization and pharmacodynamic evaluation of sustained release mucoadhesive microcapsules of venlafaxine HCl. Indian J Pharm Sci. 2014;76(4):354–63.

Duangjit S, Kraisit P. Optimization of orodispersible and conventional tablets using simplex lattice design: the relationship among excipients and banana extract. Carbohydr Polym. 2018;193:89-98.

Kraisit P, Sarisuta N. Development of triamcinolone acetonide-loaded nanostructured lipid carriers (NLCs) for buccal drug delivery using the box-behnken design. Molecules. 2018;23(4):E982.

adan J, Singh R. Formulation and evaluation of Aloe vera topical gels. Int J Phys Sci. 2010;2:551-5.

Pathan IB, Shingare PR, Kurumkar P. Formulation design and optimization of novel mouth dissolving tablets for venlafaxine hydrochloride using sublimation technique. J Pharm Res. 2013;6(6):593–98.

Sharma D, Kaur D, Verma S, Singh D, Singh M, Singh G. Fast dissolving oral films technology: a recent trend for an innovative oral drug delivery system. Int J Drug Deliv. 2015;7(2):60–75.

Kraisit P. Impact of hydroxypropyl methylcellulose (HPMC) type and concentration on the swelling and release properties of propranolol hydrochloride matrix tablets usning a simplex centroid design. Int J App Pharm. 2019;11:143-51.

Duangjit S, Kraisit P. Optimization of orodispersible and conventional tablets using simplex lattice design: the relationship among excipients and banana extract. Carbohydr Polym. 2018;193:89-98.

Sankalpa KB, Mathew SM. Response surface optimization of extraction parameters of green tea. Int J Agric Environ Biotechnol 2017;10:209.

Yu LX, Amidon G, Khan MA. Understanding pharmaceutical quality by design. AAPS J 2014;16:771–83.

Collins LM, Dziak JJ, Li R. Designof experiments with multiple independent variables:a resource management perspective on complete andreducedfactorial designs. Psychol Methods 2009;14:202–24.



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