APPLICATION OF NOVEL NATURAL MUCOADHESIVE POLYMER IN THE DEVELOPMENT OF PENTOXIFYLLINE MUCOADHESIVE TABLETS

  • ARUL BALASUBRAMANIAN Department of Pharmacy Practice, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed to be University) Salem-636 008. India
  • Gnanasekaran John Selvaraj Vinayaka Mission's Research Foundation
  • Kothai Ramalingam Vinayaka Mission's Research Foundation

Abstract

The present study was planned to develop a mucoadhesive tablet formulation of the drug pentoxifylline using natural mucoadhesive polymer from the plant Ocimum basilicum Linn. The isolated polymer was used to formulate the mucoadhesive tablets with 3 different concentrations and evaluated for various parameters such as thickness, friability, weight variation, hardness, mucoadhesive strength, swelling index, and the in-vitro drug release. The swelling index was indirectly proportional to the polymer concentration and the tablets with a high concentration of polymer showed better mucoadhesive strength. The in-vitro drug release showed that the drug release was indirectly proportional to the polymer concentration. The mechanism of drug release was found to be Fickian diffusion and followed the zero-order kinetics.

Keywords: Mucoadhesion; Ocimum basilicum; Pentoxifylline

Author Biographies

Gnanasekaran John Selvaraj, Vinayaka Mission's Research Foundation

Research Scholar

Department of Pharmacy practice,

Vinayaka Mission's College of Pharmacy

Yercaud Main Road,

Salem636008

 

Kothai Ramalingam, Vinayaka Mission's Research Foundation

Dept of Pharmacology

Vinayaka Mission's College of Pharmacy,

yercaud Main Road,

Salem-636008

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BALASUBRAMANIAN, A., John Selvaraj, G., & Ramalingam, K. (2019). APPLICATION OF NOVEL NATURAL MUCOADHESIVE POLYMER IN THE DEVELOPMENT OF PENTOXIFYLLINE MUCOADHESIVE TABLETS. International Journal of Applied Pharmaceutics, 11(6). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/35072
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