• ARUL BALASUBRAMANIAN Department of Pharmacy Practice, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed to be University) Salem-636 008. India
  • Gnanasekaran John Selvaraj Vinayaka Mission's Research Foundation
  • Kothai Ramalingam Vinayaka Mission's Research Foundation


The present study was planned to develop a mucoadhesive tablet formulation of the drug pentoxifylline using natural mucoadhesive polymer from the plant Ocimum basilicum Linn. The isolated polymer was used to formulate the mucoadhesive tablets with 3 different concentrations and evaluated for various parameters such as thickness, friability, weight variation, hardness, mucoadhesive strength, swelling index, and the in-vitro drug release. The swelling index was indirectly proportional to the polymer concentration and the tablets with a high concentration of polymer showed better mucoadhesive strength. The in-vitro drug release showed that the drug release was indirectly proportional to the polymer concentration. The mechanism of drug release was found to be Fickian diffusion and followed the zero-order kinetics.

Keywords: Mucoadhesion; Ocimum basilicum; Pentoxifylline

Author Biographies

Gnanasekaran John Selvaraj, Vinayaka Mission's Research Foundation

Research Scholar

Department of Pharmacy practice,

Vinayaka Mission's College of Pharmacy

Yercaud Main Road,



Kothai Ramalingam, Vinayaka Mission's Research Foundation

Dept of Pharmacology

Vinayaka Mission's College of Pharmacy,

yercaud Main Road,



1. Jiménez-castellanos MR Zia H, Rhodes CT. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm. 1993;19:143–94.
2. Good RJ. Definition on Adhesion. J Adhes. 1976;8:1–9.
3. Peppas NA, Buri PA. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Rel. 1985;2:257–75.
4. Longer M, Robinson J. Fundamental aspects of bioadhesion. Pharm Int. 1986;7(5):114–7.
5. Ahuja A, Khar RK Ali J. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm. 1997;23:489–515.
6. Nagai T, Machida Y. Advances in Drug Delivery, Mucosal Adhesive Dosage Forms. Pharm Int. 1985;6:196–200.
7. Gayot A. Bioadhesive polymers. J Pharm Belg. 1985;40:332–8.
8. Cilurzo F, Minghetti P, Selmin F, Casiraghi A Montanari L. Polymethacrylate salts as new low-swellable mucoadhesive materials. J Control Release. 2000;88:43–53.
9. Miyazaki S, Kawasaki N, Nakamura T Iwatsu M, Hayashi T, Hou WM, Attwood D. Oral mucosal bioadhesive tablets of pectin and HPMC: in vitro and in vivo evaluation. Int J Pharm. 2000;204:127–32.
10. Han-Gon C, Jac-Hee J, Chul Soon Y, Chong-Dal R, Mi-Kyung L, Jeong-Hee H, Kyung-mi P Chong Kook K. Formulation and in vitro evaluation of omeperazole buccal adhesive tablet. J Control Release. 2000;68:405–12.
11. Sang-Chl S J-YK. Enhanced permeation of triamcinolone acetonide through the buccal mucosa. Eur J Pharm Biopharm. 2000;40:217–20.
12. Shah HP, Prajapati ST, Patel C. Gastroretentive drug delivery systems: from conception to commercial success. J Crit Rev. 2017;4:10–21.
13. Prakash V. Leafy spices. CRC Press; 1990. 114 p.
14. Simon J, Quinn J, Murray R. Basil: A source of essential oil. In: Advances in new crops. J Janick, Simon J, editors. Timloer Press, Portland, OR; 1990. 484–489 p.
15. Marotti M, Piccaglia R, Giovanelli E. Differences in essential oil composition of basil (Ocimum basilicum L.) Italian cultivars related to morphological characteristics. J Agric Food Chemo. 1996;44:3926–29.
16. Mathews S. Ocimum basilicum: A new non-conventional source of fibre. Food Chem. 1993;47:399–401.
17. Bhosale A, Hardikar S, Pathak A, Sable R. Investigation of Hydrogel Isolated from Seeds of Ocimum basilicum as Binder. Indian J Pharm Sci. 2009;71:320–22.
18. Khazaei N, Esmaiili M, Djomeh Z, Ghasemlou M, Jouki M. Characterization of new biodegradable edible film made from basil seed (Ocimum basilicum L.) gum. Carbohydr Polym. 2014;102:199–206.
19. Akbari I, Ghoreishi S, Habibi N. Supercritical CO2 generation of nanometric structure from Ocimum basilicum mucilage prepared for pharmaceutical applications. AAPS PharmSciTech. 2015;16:428–34.
20. Naji-Tabasi S, Razavi S, Mehditabar H. Fabrication of basil seed gum nanoparticles as a novel oral delivery system of glutathione. Carbohydr Polym. 2017;157:1703–13.
21. Rayegan A, Allafchian A, Sarsari IA, Kameli P. Synthesis and characterization of basil seed mucilage coated Fe3O4 magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin. Int J Biol Macromol. 2018;113:317–28.
22. Rao PS Srivastava HC. Tamarind In: Industrial Gums. 2nd edn. RL W, editor. Academic Press, New York; 1973. 369–411 p.
23. Parodi B, Russo E, Caviglioli G, Cafaggi S, Bignardi G. Development and Characterization of a Buccoadhesive Dosage Form of Oxycodone Hydrochloride. Drug Dev Ind Pharm. 1996;22:445–50.
24. Kshirsagar R, Vikas J, Wattamwar S. Effect of different viscosity grade HPMC polymers on gastro retentive drug delivery of metformin Hcl. Int J Appl Pharm. 2009;1:44–50.
25. Gnanasekaran J, Arul B, Kothai R. Development of mucoadhesive tablet of pentoxifylline using a natural polymer from Manilkara zapota Linn. Int J Appl Pharm. 2019;11:88–91.
26. Kashappa Goud, Desai H, Pramod Kumar TM. Preparation and Evaluation of a Novel Buccal Adhesive System. AAPS PharmSci Tech. 2004;5:35–8.
27. Bagul U, Gujar K, Dhat S, Aphale S, Bhavsar M. In vitro study of mucoadhesive strength of polymers for mucoadhesive drug delivery systems. Int J Curr Pharm Res. 2009;1:42–6.
28. Patil P, Kulkarni S V, Rao B S, Ammanage A, Surpur C. Formulation and in vitro evaluation of mucoadhesive tablets of ofloxacin using natural gums. Int J ofCurrent Pharm Res. 2011;3:93–8.
29. Gupta S, Dev A. Formulation and characterization of mucoadhesive matrix tablet of nizatidine. Asian J Pharm Clin Res. 2018;11:277–83.
30. Hadjiioannou TP, Christian GD Koupparis MA. Quantitative calculations in pharmaceutical practices and research. New Delhi: NY- VCH publishers Inc; 1993. 345–348 p.
31. Higuchi T. Mechanism of sustained action of medication. Theoretical Analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 1963;52:1145–9.
32. Bourne DW. Pharmacokinetics. In: Modern Pharmaceutical. 4th ed. Banker GS, Rhodes CT E, editor. New York: Marcel. Dekker Inc.; 2002. 67–92 p.
33. Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983;15:25–36.
34. Mithal B, Kasid J. Evaluation of suspending properties of Plantago ovata (Ispaghula) seed husk. Indian J Pharm Sci. 1965;27:331–5.
35. Baveja S, Gupta B. Rheology of Aqueous dispersions of Plantago ovata seed husk-I. Indian J Pharm Sci. 1968;30:187–94.
36. Ilango R, Kavimani S, Mullaicharam AR JB. In vitro studies on buccal strips of glibenclamide using chitosan. Indian J Pharm Sci. 1997;59:232–5.
37. Saraswathi B, Balaji A, Umashankar M. Polymers in mucoadhesive drug delivery system-latest updates. Int J Pharm Pharm Sci. 2013;5:423–30.
38. Park H, Robinson JR. Mechanisms of mucoadhesion of poly(acrylic acid) hydrogels. Pharm Res. 1987;4:457–64.
39. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 1985;60:110–1.
40. Kumar BP, Kavitha P, Devi KJ. Formulation design and evaluation of mucoadhesive buccal tablets of nitroglycerin. Int J Pharm Pharm Sci. 2014;6:251–9.
41. Sood A, Panchagnula R. Drug Release Evaluation of Diltiazem CR Preparations. Int J Pharm. 1998;175:95–107.
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BALASUBRAMANIAN, A., John Selvaraj, G., & Ramalingam, K. (2019). APPLICATION OF NOVEL NATURAL MUCOADHESIVE POLYMER IN THE DEVELOPMENT OF PENTOXIFYLLINE MUCOADHESIVE TABLETS. International Journal of Applied Pharmaceutics, 11(6). Retrieved from
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