CYP2D6 PHENOTYPES AMONG JAVANESE AND SUNDANESE SUBJECTS IN INDONESIA

  • PRI ISWATI UTAMI Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Jl. Raya Dukuhwaluh, Kembaran, Purwokerto, Central Java, Indonesia. Post Graduate Program, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia
  • SUGIYANTO SUGIYANTO Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia.
  • SUDIBYO MARTONO Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia.
  • LUKMAN HAKIM Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia.

Abstract

Objective: The objective of this study was to determine CYP2D6 phenotype in a Javanese and Sundanese healthy subject in Indonesia.
Methods: Ninety unrelated healthy Indonesian subjects from Java and Sunda were studied. Metoprolol was used as phenotyping substrate. A 100 mg
oral tablet of metoprolol was administered to all the subjects. Urinary metoprolol and α-hydroxymetoprolol were determined to calculate metoprolol
metabolic ratio (MR). Determination of metoprolol and α-hydroxymetoprolol was carried out by high performance liquid chromatography method.
Results: Metoprolol MR varied widely (from 0.08 to 72.75). One subject (1.11%) in the study was classified as poor metabolizer (PM), one subject
(1.11%) as ultrarapid metabolizer, and the remaining 88 subjects (97.78%) were classified as extensive metabolizers.
Conclusion: The frequencies of PM for the CYP2D6 phenotype (1.11%) in the Javanese and Sundanese population are in concordance with most
results of oxidation metabolizers in other Asian populations.

Keywords: CYP2D6, Javanese and Sundanese, Indonesia, Metoprolol, Phenotype

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UTAMI, P. I., SUGIYANTO, S., MARTONO, S., & HAKIM, L. (2019). CYP2D6 PHENOTYPES AMONG JAVANESE AND SUNDANESE SUBJECTS IN INDONESIA. International Journal of Applied Pharmaceutics, 11(5), 36-39. https://doi.org/10.22159/ijap.2019.v11s5.T0038
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