TOPICAL ANTI-PSORIATIC NANOPARTICULATE DRUG DELIVERY SYSTEM

  • Kiran Bhise Principal & Professor
  • Shadab Assistant Professor, Allana College of Pharmacy, Pune
  • Ghazala Associate Professor, Unani Medical College, Azam Campus, Pune

Abstract

Development of effective drug delivery in the treatment of psoriasis is the major challenge for its successful management. The aim of the present work was to develop and assess the potential of Nanostructured Lipid Carriers (NLCs) enriched with the powdered leaves extracts of Azadirachta indica (AE), Lawsonia inermis (LE) and fruit extract of Mallotus philippensis (ME).  Drug loaded NLCs were prepared via hot homogenization technique by adopting 23 factorial design with factors X1 as concentration of lipids, X2 concentration of surfactants and X3 being number of homogenization cycle. The responses Y1 and Y2 were particle size and zeta potential. The optimized batch was obtained from Surface response plot and was found within the nanosized range with relatively low polydispersity index and zeta potential of -20mV. The optimized batch of NLCs was subjected to % entrapment efficiency which was found to be 98.97%, 96.99% and 99.25% and % drug loading was found to be 21.84%, 8.55% and 87.91% respectively for AE, LE and ME. The SEM images showed the spherical vesicular structures of drugs loaded NLCs. The in vitro diffusion of drugs from the NLCs followed initial burst release thereafter sustained release for 24 hours. The AE, LE and ME loaded NLCs proved to possess anti-lipid peroxidation and nitric oxide scavenging activities, cytotoxicity on HaCat cell lines, DNA fragmentation on HaCat cell lines which are biomarker in pathogenesis of psoriasis. The results of Mouse Tail and Rat ultraviolet ray B photodermatitis models for Psoriasis supported anti-psoriatic potential of AE, LE and ME loaded NLCs.

Keywords: Psoriasis, Drug Extracts, Nanostructured Lipid Carriers, Evaluation

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Bhise, K., Khan, S., & Mulla, G. (2020). TOPICAL ANTI-PSORIATIC NANOPARTICULATE DRUG DELIVERY SYSTEM . International Journal of Applied Pharmaceutics, 12(2). Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/36536
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