FORMULATION AND EVALUATION OF LIQUID CRYSTAL EMULSION CONTAINING EXTRA VIRGIN OLIVE OIL AS SKIN ANTI-AGING
Keywords:Liquid crystal emulsion, Extra virgin olive oil, Skin anti-aging
Objective: The purpose of this research was to formulate and evaluate the and anti-aging activity and the characteristic of liquid crystal emulsion of extra virgin olive oil (EVOO).
Methods: Preparation of liquid crystal emulsion was made using the variation of alkyl polyglycoside and caprylic triglyceride as surfactant with concentration ratio was 3:5 (F1), 4:4 (F2), 5:3 (F3) and 5% extra virgin olive oil as an anti-aging substance. The liquid crystal emulsions were evaluated for an organoleptic test, microscopic, pH value, viscosity, particle size, zeta potential during 12 w storage at room temperature and centrifugation test. The selected liquid crystal emulsion was examined with anti-aging activity (moisture, pore, spot, and wrinkle) using a skin analyzer to volunteer’s skin.
Results: The result showed that all formulas had stable storage for 12 w at room temperature (25±1 °C). Liquid crystal emulsion with a surfactant concentration of alkyl polyglycosides and caprylic triglycerides 4:4 (F2) showed the presence of liquid crystal, the stable value of pH (6.9) and viscosity (4995 mPa), smallest particle size 5.727 µm, and highest zeta potential-34.5 mV after 12 w storage at room temperature.
Conclusion: EVOO liquid crystal emulsion (F2) showed better skin anti-aging activity (condition of moisture content, pore, spot, and wrinkle) than conventional emulsion. It concluded that the formula was stable physically and showed better skin anti-aging activity than conventional emulsion.
Nazliniwaty N, Suryanto S, Damanik DD. The utilization of binahong (Anredera cordifolia (Ten.) Steenis) leaf as an anti-aging. Asian J Pharm Clin Res 2018;11:87.
Iya A, Geeta A, Gitika AD, Manju N. Herbal active ingredients used in skin cosmetics. Asian J Pharm Clin Res 2019;12:7–15.
Yaar M, Gilchrest BA. Photoaging: mechanism, prevention, and therapy. Br J Dermatol 2007;157:874-7.
Oliveira LB, Oliveira RF, Oliveira C, Raposo NR, Bradão MA, Ferreira AO, et al. Cosmetic potential of a liotropic liquid crystal emulsion containing resveratrol. Cosmetics 2017;7:1-3.
Santis SD, Cariello M, Piccinin E, Sabbà C, Moschetta A. Extra virgin olive oil: lesson from nutrigenomics. Nutrients 2019;11:2.
Viola P, Viola M. Virgin olive oil as a fundamental nutritional component and skin protector. Clin Dermatol 2009;27:159-60.
Orey C. Benefits of olive oil mediterranean longevity recipe. Jakarta: Hikmah; 2008. p. 10.
Waterman E, Lockwood B. Active components and clinical applications of olive oil. Altern Med Rev 2007;12:331-2.
Bernegossi J, Barbosa RM, Rustice PM, Chorilli M. Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control. Braz J Pharm Sci 2016;52:383-7.
Zanatta CF, de Faria Sato AC, de Camargo Junior FB, Campos PM, Rocha-Filho PA. Rheological behavior, zeta potential, and accelerated stability test of buriti oil (Mauritia flexuosa) emulsions containing the lyotropic liquid crystal. Drug Dev Ind Pharm 2010;36:93-101.
Zhang W, Liu L. Study on the formation and properties of liquid crystal emulsion in cosmetics. J Cosmet Dermatol Sci 2013;3:139-41.
Preziosi V, Perazzo A, Caserta S, Tomaiuolo G, Guido S. Phase inversion emulsification. Chem Eng Trans 2013;32:1585-90.
Föster TH, Schambil F, Tesmann H. Emulsification by the phase inversion temperature method: the role of self-bodying agents and the influence of oil polarity. Int J Cosmetic Sci 1990;12:217-27.
Fernandez P, Andre V, Rieger J, Kühnle A. Nano-emulsion formation by emulsion phase inversion. Colloids Surface A 2004;251:53-8.
Terescenco D, Picard C, Clemenceau F, Grisel M, Savary G. Influence of the emollient structure on the properties of cosmetic emulsion containing lamellar liquid crystals. Colloids Surface A 2017;25:10-9.
Medina WS, Praça FS, Carollo AR, Bentley MV. Nanocarriers to deliver photosensitizers in topical photodynamic therapy and photodiagnostivs. In: Beck R, Guterres S, Pohlmann A. Nanocosmetics and Nanomedicines; 2011. p. 298-9.
Friberg SE. Micelles, microemulsions, liquid crystals, and the structure of stratum corneum lipids. J Soc Cosmet Chem 1990;41:155-71.
Harry RG. Harry’s Cosmetology. Seventh Edition. London: Leonard Hill Book; 2000. p. 108.
Alam MM, Aramaki K. Liquid crystal-based emulsions: progress and prospect. J Oleo Sci 2014;63:97-108.
Stepien JB, Jaremek H, Pielak GF. Liquid-crystal emulsion oil in water type and a preparation method of the liquid-crystal emulsion. US008658058B2; 2014. p. 2.
Gao L, Zhang D, Chen M. Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. J Nanopart Res 2008;10:845–62.
Andrade FF, Santos OD, Oliviera WP, Rocha Filho PA. Influence of PEG-12 dimethicone addition on stability and formation of emulsions containing liquid crystal. Int J Cosmetic Sci 2007;29:211-8.
Lachman L, Lieberman HA, Kanig JL. Theory and practice of Industrial pharmacy. Jakarta: Universitas Indonesia Press; 1994.
Lin T, Zhong L, Santiago JL. Anti-Inflammatory and skin barrier repair effect of topical application of some plant oils. Int J Mol Sci 2018;19:4.
Iwai H, Fukasaw J, Suzuki T. A liquid crystal application in skincare cosmetics. Int J Cosmetic Sci 1998;20:87-102.
Musashi M, Coler Reilly A, Nagasawa T, Kubota Y, Kato S, Yamaguchi Y. Liquid crystal gel reduces age spots by promoting skin turnover. Cosmetics 2014;25:202-10.