• Anayanti Arianto Department of Pharmaceutical Techology, Faculty of Pharmacy, Universitas Sumatera Utara
  • Ulva Dwi Ayu Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia
  • Julia Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia


Extra virgin olive oil contains unsaturated fatty acid and phenolic antioxidants such as can give protection against skin aging process. One of the most innovative delivery systems for cosmetic products is liquid crystal emulsion. The advantage of this system is a more stable system than conventional emulsion because can prevent phase separation in the liquid crystal system.  This research was aimed to formulate and evaluate the and anti-aging activity and the characteristic of liquid crystal emulsion of extra virgin olive oil (EVOO). Preparation of liquid crystal emulsion was made using the variation of alkyl polyglycoside and caprylic triglyceride as surfactant with concentration ratio was 3:5 (F1), 4:4 (F2), 5:3 (F3) and 5% extra virgin olive oil as an anti-aging substance. The liquid crystal emulsions were evaluated for organoleptic test, microscopic, pH value, viscosity, particle size, zeta potential during 12 weeks storage at room temperature and centrifugation test. The selected liquid crystal emulsion was examined with anti-aging activity (moisture, pore, spot, and wrinkle) using a skin analyzer to volunteer’s skin. The result showed that all formulas had stable in  storage for 12 weeks at room temperature (25±1°C). Liquid crystal emulsion with a surfactant concentration of alkyl polyglycosides and caprylic triglycerides 4:4 (F2) showed the presence of liquid crystal, the stable value of pH (6.9) and viscosity (4995 mPa), smallest particle size 5.727 µm, and highest zeta potential -34.5 mV after 12 weeks storage at room temperature. EVOO liquid crystal emulsion (F2) showed better skin anti-aging activity (condition of moisture content, pore, spot, and wrinkle) than conventional emulsion. It concluded that the formula was stable physically and show better skin anti-aging activity than conventional emulsion.

Keywords: liquid crystal emulsion, extra virgin olive oil, skin anti-aging


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Arianto, A., Septianingsih, U. D. A., & reveny, J. (2020). FORMULATION AND EVALUATION OF LIQUID CRYSTAL EMULSION CONTAINING EXTRA VIRGIN OLIVE OIL AS SKIN ANTI-AGING. International Journal of Applied Pharmaceutics, 12(4). Retrieved from
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