• PRAJWAL A. T. Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, Karnataka 576104, India
  • MUDDUKRISHNA B. S. Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, Karnataka 576104, India
  • S. G. VASANTHARAJU Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal, Karnataka 576104, India


The IoT in health care is currently booming in the world of health care in particular. Industry has risen from generation 1.0 to 4.0 during the Internet of things period. As we remember, we came across the exact submission of the traditional health care system. Each time the patient has needed to visit the clinic/hospitals, even for small complications that may affect the patient's medical costs along with time and energy. One more significant factor is also an emergency; otherwise, she/he/older population was unable to demand urgent assistance from the older system of healthcare. And yet somehow, the situation has changed with the use of the cyber-physical world; we are heading out of the 4th phase of the health care industry means smart health care network. This paper offers an insight into different facets of how healthcare systems such as doctors, hospitals, and of course, patients are powered by the internet of things and how can it track and ensure fast, quality, and efficient use of less time also in a smart way. Here, a patient knows how to track patients by using a collection of different wearable sensor nodes for real-time monitoring and examination of specific patient criteria. One of the most boosting subjects characterizes the development of medical technology within their own homes, enabling older or physically weak people to stay as long as possible at home while being medically cared for and monitored.

We searched literature and guidelines in Pubmed, Web of Science, Google Scholar, Scopus, CNKI, and Embase databases up to 2019. The following search terms alone or matched with the Boolean operators ‘AND’ or ‘OR’ were used: "Nanoparticles", “Anticancer treatment", ‘Bioflavonoids’, ‘Plant origin drugs’, ‘Nano formulations’, ‘Cancer’ and ‘Novel drug delivery systems’. We focused on full-text articles, but abstracts were considered if relevant.

Keywords: IoT, Pharma 4.0, Hospital management, Physician, BP monitoring, Smart clothing, ECG monitoring, Glucose monitoring, Health care


1. Adams DQ. What has industry 4.0 got to do with us? A review of the Literature. South Afr 2018. p. 19.
2. Kumari A, Tanwar S, Tyagi S, Kumar N. Fog computing for Healthcare 4.0 environment: opportunities and challenges. Comput Electr Eng 2018;72:1–13.
3. Olsen TL, Tomlin B. Industry 4.0: opportunities and challenges for operations management. Manuf Serv Oper Manag 2020;22:113–22.
4. Markarian J. The pharmaceutical industry is adopting Industry 4.0 and emerging technologies to improve product quality and manufacturing efficiency; 2018. p. 5.
5. Ding B. Pharma Industry 4.0: Literature review and research opportunities in sustainable pharmaceutical supply chains. Process Saf Environ Prot 2018;119:115–30.
6. Wang P, Valerdi R, Zhou S, Li L. Introduction: advances in IoT research and applications. Inf Syst Front 2015;17:239–41.
7. Hu F, Xie D, Shen S. On the application of the internet of things in the field of medical and health care. In: 2013 IEEE International Conference on Green Computing and Communications and IEEE Internet of Things and IEEE Cyber, Physical and Social Computing [Internet]. Beijing, China: IEEE; 2013. p. 2053–8. Available from: [Last accessed on 21 Apr 2020]
8. Ahmed E, Rehmani MH. Introduction to the special section on social collaborative internet of things. Comput Electr Eng 2017;58:382–4.
9. Markendahl J, Lundberg S, Kordas O, Movin S. On the role and potential of IoT in different industries: Analysis of actor cooperation and challenges for the introduction of new technology. In: Internet of Things Business Models, Users, and Networks [Internet]. Copenhagen: IEEE; 2017. p. 1–8. Available from: [Last accessed on 21 Apr 2020]
10. Maharshi Dayanand University, Rohtak, India, Mittal P. A survey on internet of things (IoT) based healthcare monitoring system. Int J Adv Trends Comput Sci Eng 2019;6:1646–53.
11. Bansal M, Gandhi B. IoT based development boards for smart healthcare applications. In: 2018 4th International Conference on Computing Communication and Automation (ICCCA) [Internet]. Greater Noida, India: IEEE; 2018. p. 1–7. Available from: [Last Accessed on 21 Apr 2020]
12. R A, L CSM, R N, R A. Pharma tourism: building a healthy and wealthy India. Asian J Pharm Clin Res 2016;9:27–9.
13. Mesko B, Drobni Z, Benyei E, Gergely B, Gyorffy Z. Digital health is a cultural transformation of traditional healthcare. mHealth 2017. Available from: view/16494 [Last accessed on 22 Apr 2020].
14. Kasthuri A. Challenges to Healthcare in India-The Five A’s. Indian J Community Med Off Publ Indian Assoc Prev Soc Med 2018;43:141–3.
15. Ud Din I, Almogren A, Guizani M, Zuair M. A decade of internet of things: analysis in the light of healthcare applications. IEEE Access 2019;7:89967–79.
16. Sandison B. Australian Institute of Health and Welfare. Impact 2018;2018:80–1.
17. Yin Y, Zeng Y, Chen X, Fan Y. The internet of things in healthcare: an overview. J Ind Inf Integr 2016;1:3–13.
18. Datta SK, Paul TR, Monwar M, Khatun A, Islam MR, Ali MA, et al. Patterns of Prescription and Antibiotic use among outpatients in a tertiary care teaching Hospital of Bangladesh. Int J Pharm Pharm Sci 2016;8:60–3.
19. Nausheen F, Begum SH. Healthcare IoT: benefits, vulnerabilities and solutions. In: 2018 2nd International Conference on Inventive Systems and Control (ICISC) [Internet]. Coimbatore: IEEE; 2018. p. 517–22. Available from: [Last accessed on 21 Apr 2020]
20. Lamonaca F, Balestrieri E, Tudosa I, Picariello F, Carni DL, Scuro C, et al. An Overview on Internet of Medical Things in Blood Pressure Monitoring. In: 2019 IEEE International Symposium on Medical Measurements and Applications (MeMeA) [Internet]. Istanbul, Turkey: IEEE; 2019. p. 1–6. Available from: [Last accessed on 22 Apr 2020]
21. Bolivar Pulgarin NG, Cangrejo Aljure LD, Salcedo Parra OJ. eHeart-BP, prototype of the internet of things to monitor blood pressure. In: 2019 IEEE/ACM International Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE) [Internet]. Arlington, VA, USA: IEEE; 2019. p. 58–63. Available from: document/8908647/ [Last accessed on 22 Apr 2020]
22. Singh B, Urooj S, Mishra S, Haldar S. Blood pressure monitoring system using wireless technologies. Procedia Comput Sci 2019;152:267–73.
23. Musyoka FM, Thiga MM, Muketha GM. A 24 h ambulatory blood pressure monitoring system for preeclampsia management in antenatal care. Inform Med Unlocked 2019;16:100199.
24. Cho H, Lee J. A development of the design prototype of smart healthcare clothing for silver generation based on bio-medical sensor technology. In: Jacko JA. editor. Human-Computer Interaction Interaction Platforms and Techniques [Internet]. Berlin, Heidelberg: Springer Berlin Heidelberg; 2007. p. 1070–7. Available from: [Last accessed on 23 Apr 2020]
25. Chen M, Ma Y, Song J, Lai CF, Hu B. Smart clothing: connecting human with clouds and big data for sustainable health monitoring. Mob Netw Appl 2016;21:825–45.
26. Schaar AK, Ziefle M. Smart clothing: perceived benefits vs. perceived fears. In: Proceedings of the 5th International ICST Conference on Pervasive Computing Technologies for Healthcare [Internet]. Dublin, Republic of Ireland: IEEE; 2011. Available from: icst.pervasivehealth.2011.246031. [Last accessed on 23 Apr 2020].
27. Axisa F, Schmitt PM, Gehin C, Delhomme G, McAdams E, Dittmar A. Flexible technologies and smart clothing for citizen medicine, home healthcare, and disease prevention. IEEE Trans Inf Technol Biomed 2005;9:325–36.
28. Cho H, Lee JH. A study on the optimal positions of ECG electrodes in a garment for the design of ECG-monitoring clothing for male. J Med Syst 2015;39:95.
29. Ariyatum B, Holland R, Harrison D, Kazi T. The future design direction of smart clothing development. J Text Inst 2005;96:199–210.
30. Serhani MA, T El Kassabi H, Ismail H, Nujum Navaz A. ECG monitoring systems: review, architecture, processes, and key challenges. Sensors 2020;24;20:1796.
31. Liu C, Zhang X, Zhao L, Liu F, Chen X, Yao Y, et al. Signal quality assessment and lightweight QRS detection for wearable ECG smart vest system. IEEE Int Things J 2019;6:1363–74.
32. Li C, Hu X, Zhang L. The IoT-based heart disease monitoring system for pervasive healthcare service. Procedia Comput Sci 2017;112:2328–34.
33. Brezulianu A, Geman O, Zbancioc MD, Hagan M, Aghion C, Hemanth DJ, et al. IoT based heart activity monitoring using inductive sensors. Sensors 2019;26;19:3284.
34. Ramesh GP, Kumar NM. Design of RZF antenna for ECG monitoring using IoT. Multimed Tools Appl 2020;79:4011–26.
35. Poonguzhali S, Chakravarthy R. A non-invasive multi-faced problem-solving tool in a dynamic sensor network for pediatric diabetes with fall detection. In: 2019 2nd International Conference on Power and Embedded Drive Control (ICPEDC). Chennai, India: IEEE; 2019. p. 493–8.
36. Fernandez Carames TM, Froiz Miguez I, Blanco Novoa O, Fraga Lamas P. Enabling the internet of mobile crowdsourcing health things: a mobile fog computing, blockchain and IoT based continuous glucose monitoring system for diabetes mellitus research and care. Sensors 2019;19:3319.
37. Alarcon Paredes A, Francisco Garcia V, Guzman Guzman IP, Cantillo Negrete J, Cuevas Valencia RE, Alonso Silverio GA. An IoT-based non-invasive glucose level monitoring system using raspberry pi. Appl Sci 2019;9:3046.
38. Farhat J, Shamayleh A, Al-Nashash H. Medical equipment efficient failure management in IoT environment. In: 2018 Advances in Science and Engineering Technology International Conferences (ASET). Abu Dhabi: IEEE; 2018. p. 1–5.
39. Ranjbar E, Sedehi RG, Rashidi M, Suratgar AA. Design of an IoT-based system for smart maintenance of medical equipment. In: 2019 3rd International Conference on Internet of Things and Applications (IoT) [Internet]. Isfahan, Iran: IEEE; 2019. p. 1–12.
40. Anandarajan M, Malik S. Protecting the Internet of medical things: A situational crime-prevention approach. Schumacher U, editor. Cogent Med; 2018. Available from: [Last accessed on 24 Apr 2020]
41. IoT Enabled Healthcare Equipment Market Market Global Strategies and Opportunities To 2023. Available from: [Last accessed on 24 Apr 2020]
42. Park Y, Park Y. A selective group authentication scheme for IoT-based medical information system. J Med Syst 2017;41:48.
43. Babu MR. Design and development of low investment smart hospital using the internet of things through innovative approaches. Biomed Res 2017;28:7.
44. Djelouat H, Amira A, Bensaali F, Boukhennoufa I. Secure compressive sensing for ECG monitoring. Comput Secur 2020;88:101649.
45. Divakaran S, Manukonda L, Sravya N, Morais MM, Janani P. IOT clinic-Internet based patient monitoring and diagnosis system. In: 2017 IEEE International Conference on Power, Control, Signals and Instrumentation Engineering (ICPCSI) [Internet]. Chennai: IEEE; 2017. p. 2858–62.
46. Latif G, Shankar A, Alghazo JM, Kalyanasundaram V, Boopathi CS, Arfan Jaffar M. I-CARES: advancing health diagnosis and medication through IoT. Wirel Netw 2020;26:2375–89.
47. Mannan A, Mubeen H. Digitalisation and automation in pharmaceuticals from drug discovery to drug administration. Int J Pharm Pharm Sci 2018;10:1–10.
48. Vippalapalli V, Ananthula S. Internet of things (IoT) based smart health care system. In: 2016 International Conference on Signal Processing, Communication, Power and Embedded System (SCOPES). Paralakhemundi, Odisha, India: IEEE; 2016. p. 1229–33.
49. Techutzpah. Internet of Things (IoT) Healthcare Benefits. Medium. 2018. Available from: internet-of-things-iot-healthcare-benefits-2aae663c5c79. [Last accessed on 25 Apr 2020].
50. Santhi V, Ramya K, Tarana A, Vinitha G. IOT based wearable health monitoring system for pregnant ladies using CC3200. Int J Adv Res Methodol Eng Technol 2017;1:56-60.
51. IoT in Healthcare Industry | IoT Applications in Healthcare-Wipro. Available from: [Last accessed on 25 Apr 2020].
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How to Cite
A. T., P., B. S., M., & VASANTHARAJU, S. G. (2020). PHARMA 4.0–IMPACT OF THE INTERNET OF THINGS ON HEALTH CARE. International Journal of Applied Pharmaceutics, 12(5), 64-69.
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