Development of Binary and Ternary complex of Cefuroxime Axetil with Cyclodextrin for Improving Pharmaceutical Characteristics

Binary and Ternary complex of Cefuroxime Axetil with Cyclodextrin

  • Sakshi Kaushik Research Scholar
  • Ravinder Verma Research Scholar
  • Deepika Purohit Assistant Professor, of Pharmaceutical Sciences, Indra Gandhi University, Meerpur, Rewari, India
  • Parijat Pandey Assistant Professor, Shri Baba Mastnath Institute of Pharmaceutical Sciences and Research, Baba Mastnath University, Rohtak (Haryana), India – 124001
  • Manish Kumar Professor, M .M. College of Pharmacy, Mullana, Ambala, Haryana
  • Beena Kumari Assistant Professor, Department of Pharmaceutical Sciences, Indra Gandhi University, Meerpur, Rewari, India
  • Deepak Kaushik Assistant Professor, Department of Pharmaceutical Sciences, M.D. University, Rohtak



Objective: The objective of the current research is systematic development and characterization of binary and ternary inclusion complexes of Cefuroxime axetil with β-Cyclodextrin to improve its Pharmaceutical characteristics by using kneading method.

Method: Phase solubility study was carried out using Higuchi and Connors method. Based on its result, binary complexes of Cefuroxime axetil with different ratio of β-Cyclodextrin were developed and characterized using DSC, FT-IR and XRD. Then, binary complex were analyzed for in vitro dissolution testing. The ternary complex were developed using different ratio of PVP K-30 as ternary component and evaluated for in vitro dissolution testing and in vitro taste masking.

Results: Binary complex of Cefuroxime axetil with β-Cyclodextrin (1:1) showed better drug release in comparison to pure drug. During the development of ternary complex, β-Cyclodextrin (1:1) and 1% w/v PVP K-30 as ternary agent resulted in optimized ternary complex. The DSC, FT-IR and XRD studies clearly revealed the formation of binary and ternary complexes. The ternary complex showed better drug release of >85% drug release within 30 min. in comparison to binary complex. The in vitro taste masking study revealed the taste masking efficiency of ternary complex of cefuroxime with β-Cyclodextrin.

Conclusion: The developed binary and ternary complex of Cefuroxime axetil based on β-Cyclodextrin with PVP K-30 showed improved in vitro dissolution rate and taste masking in comparison to pure drug. The drug release was better in ternary complexes. The present research work successfully shows the utility of binary and ternary complexes for improving Pharmaceutical characteristics of Cefuroxime axetil.

Keywords: Cefuroxime axetil, inclusion complex, binary complex, ternary complex, cyclodextrin, kneading method, bioavailability, beta- cyclodextrin


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Sakshi Kaushik, Ravinder Verma, Deepika Purohit, Parijat Pandey, Manish Kumar, Beena Kumari, & Deepak Kaushik. (2020). Development of Binary and Ternary complex of Cefuroxime Axetil with Cyclodextrin for Improving Pharmaceutical Characteristics. International Journal of Applied Pharmaceutics, 12(6). Retrieved from
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