• RAKESH PAHWA Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, 136119 India
  • BIGUL YOGESHVER BHARDWAJ Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, 136119 India
  • ARCHANA SHARMA Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, 136119 India
  • MONA PIPLANI School of Pharmacy, Maharaja Agrasen University, Baddi, Dist, Solan, Himachal Pradesh, 174103 India
  • MANISH KUMAR M M College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, 133207 India


Helicobacter pylori is a virulent human pathogen infecting about 50% of the population worldwide. Being a leading cause of gastric ulcer, duodenal ulcer, gastritis, dyspepsia, gastric tumorigenesis etc., this organism has been the focus of concerted study to establish uncertainty of its genetics, immunopathogenesis and cell biology. Scientists have tried to effectively eradicate this pathogen from the gastrointestinal tract in various manners. Inquest of this venture, gastroretentive drug delivery systems including floating dosage forms have emerged as a boon and offer significantly improved therapeutic effects of different antimicrobial drugs. This article presents an evocative review of the structural features, epidemiological evidences and various pharmacotherapeutics vistas. In addition, various novel gastroretentive dosage forms developed so far to combat Helicobacter pylori infection are also discussed. Comprehensive literature review has been performed for this manuscript by utilizing relevant databases like PubMed, SCOPUS, Web of Science, Science Direct, Google Scholar etc., from 1997 up to the year 2020.

Keywords: Helicobacter pylori, Gastric ulcer, Pharmacotherapeutic vistas, Gastroretentive technology, Floating dosage forms


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