IN SITU GEL POLYMERS: A REVIEW

  • MOUNIKA KONATHAM School of Pharmacy, Anurag University (Formerly Anurag Group of Institutions), Venkatapur, Medchal, Hyderabad 500088, Telangana State, India
  • MOUNIKA TEJASWI GORLE School of Pharmacy, Anurag University (Formerly Anurag Group of Institutions), Venkatapur, Medchal, Hyderabad 500088, Telangana State, India
  • NAVEEN PATHAKALA School of Pharmacy, Anurag University (Formerly Anurag Group of Institutions), Venkatapur, Medchal, Hyderabad 500088, Telangana State, India, Department of Pharmacy, University College of Technology, Osmania University, Hyderabad 500007, Telangana, India
  • VASUDHA BAKSHI School of Pharmacy, Anurag University (Formerly Anurag Group of Institutions), Venkatapur, Medchal, Hyderabad 500088, Telangana State, India
  • YASO DEEPIKA MAMIDISETTI Career Point University, Kota, Aalniya, Rajasthan 324005, India
  • PRIYANKA CHINTHAKINDI Department of Biotechnology,Chaitanya College of Pharmacy Education and Research, Kakatiya University, Kishanpura, Hanamkonda, Warangal 506001, Telangana, India
  • RAJENDRA KUMAR JADI School of Pharmacy, Anurag University (Formerly Anurag Group of Institutions), Venkatapur, Medchal, Hyderabad 500088, Telangana State, India, Department of Pharmacy, University College of Technology, Osmania University, Hyderabad 500007, Telangana, India

Abstract

In situ gels have become one of the most prominent and accessible systems. These systems have several advantages like simple manufacturing, easy to use, improved adherence, and patient comfort by minimizing drug administration frequency by its unique characteristic features of sol to gel transition. In the 'sol-gel' method, the precursor goes through hydrolysis and polymerization or condensation to produce a colloidal suspension or solution. As they can administer in solution form, these in situ gelling systems undergo gelation at the achievement site. Some researchers recently developed in situ gelling systems of liposomes, microspheres, nanoemulsions, nanospheres, etc. This review mainly focused on the introduction, advantages, disadvantages, types of polymers, and suitable characteristics for preparing in situ gels.

Keywords: In situ gels, Polymer, Sol-gel, Gelation, Transition

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KONATHAM, M., GORLE, M. T., PATHAKALA, N., BAKSHI, V., MAMIDISETTI, Y. D., CHINTHAKINDI, P., & JADI, R. K. (2021). IN SITU GEL POLYMERS: A REVIEW. International Journal of Applied Pharmaceutics, 13(1), 86-90. https://doi.org/10.22159/ijap.2021v13i1.39504
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