DEVELOPMENT OF A PROLONGD RELEASE GASTRORETENTIVE TABLET FORMULATION OF LEVOFLOXACIN
Objective: The present investigation concerns the design and evaluation of floating tablets of Levofloxacin, which after oral administration prolong the gastric residence time and increased drug bioavailability.
Methods: Levofloxacin is a synthetic chemotherapeutic agent used to treat severe or life-threatening bacterial infections. The present work was designed to formulate floating tablet of Levofloxacin with various swelling agents. Formulations were prepared using various concentrations of Guar gum, Carbopol, hydroxy propyl methyl cellulose and Ethyl Cellulose by direct compression technique. The selected batches were evaluated for various parameters like weight variation, thickness, diameter, friability, floating lag time, duration of floating, swelling index, content uniformity and in-vitro drug release. The data obtained from the in-vitro dissolution studies of optimized batch F7 were fitted in different models.
Results: The optimized formulation F7 showed 99.25% drug content, floating lag time of 10 min and swelling index of 40%. Drug release mechanism was found to be zero order along with higuchi release kinetics exhibiting diffusion along with dissolution of the drug from the tablet by non fickian mechanism.
Conclusion: Levofloxacin floating tablets exhibited increased gastric residence time, there by improved bioavailability and therapeutic effect of the drug.
Keywords: Levofloxacin, Gastro retentive, Guar gum, Hydroxy propyl methyl cellulose, Ethyl Cellulose, Carbopol.
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