MYRICETIN NANO-PHYTOSOMES PEEL-OFF GEL MASK FORMULATION AS ANTIOXIDANT

  • NUR AINI DEWI PURNAMASARI Departement of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Setia Budi University, Surakarta, Indonesia
  • MUHAMMAD DZAKWAN Departement of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Setia Budi University, Surakarta, Indonesia
  • GANET EKO PRAMUKANTORO Departement of Clinical Pharmacy, Faculty of Pharmacy, Setia Budi University, Surakarta, Indonesia
  • RACHMAT MAULUDIN Departement of Pharmaceutic, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
  • ELFAHMI Departement of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia

Abstract

Objective: Peel-off gel mask is an alternative preparation which can increase the convenience of use and is expected to increase the antioxidant activity of myricetin nano-phytosomes. Myricetin has various activities, namely as a natural antioxidant, anti-inflammatory, allergy, and anti-cancer. This study aims to determine the nano-phytosome myricetin can be formulated into a gel peel-off mask, determine the concentration of PVA which has the best physical properties of the gel peel-off mask, and determine the antioxidant activity.


Method: The thin layer hydration method was used to manufacture Myricetin nano-phytosomes, then dried using the freeze-drying method. The resulting nano-phytosome characterization included particle size, polydispersion index, zeta potential and absorption efficiency. Peel-off gel masks were made with variations in the concentration of the PVA gelling agent, namely F1 3.5%, F2 7%, F3 14%. The resulting peel-off gel mask was tested for physical quality including organoleptic test, homogeneity, pH, viscosity, adhesion, drying time and testing for antioxidant activity.


Result: The resulting peel-off gel mask has good physical quality and met the existing requirements, where the different PVA concentrations resulted in different physical qualities, the higher the PVA, the faster the dry time. All three formulas have very strong antioxidant activity.


Conclusion: Myricetin nano-phytosomes can be formulated into a gel peel-off mask, Formula 2 with a 7% concentration of PVA produces the best physical quality of the peel-off gel mask, the three gel peel-off mask formulas have excellent antioxidant activity with an IC50 value of F1 14.8 ppm, F2 15.37 ppm, and F3 15.87 ppm.

Keywords: Peel-off gel mask, myricetin nano-phytosomes, PVA, antioxidant.

References

1. Pratiwi L, Wahdaningsih S. Formulasi Dan Aktivitas Antioksidan Masker Wajah Gel Peel-off Ekstrak Metanol Buah Pepaya (Carica Papaya L.). Pharmacy Medical Journal 2008;1 (2).
2. Armadany FI, Hasnawati, Sirait M. Formulasi Sediaan Masker Gel Peel-off Antioksidan dari Ekstrak Sari Tomat (Solanum lycopersicum L. var. cucurbita).Pharmauho, Majalah Farmasi, Sains, dan Kesehatan,1;2: 29-32.
3. Rahmawanty D, Yulianti N, Fitriana M. Formulasi dan Evaluasi Masker Wajah Peel-off meangandung Kuersetin dengan Variasi Konsentrasi Gelatin. Media Farmasi 2015; 12 (1): 17-32.
4. Hasyim N, Faradiba, Gina, AB. Formulasi Gel Sari Buah Belimbing Wuluh (Averrhoa bilimbi L.), Majalah Farmasi dan Farmakologi 2011; 15(1) : 5-9.
5. Chakraborty S, Vadakkekara A, George N, Bhagyasree T, Mary L. Application and Stability Evaluation of Polymer blends in Cosmetics. International Journal for Research in Applied Science & Engineering Technology 2017; 5(9):849-861.
6. Andre B. Green clay and oloe vera peel of facial masks: response surface methodology applied to the formulation design. American Association of Pharmaceutical Scientists 2013;14(1): 445-455.
7. Anese M, Lara M, Maria CN. Antioxidant Properties Of Tomato Juice As Accected By Heating, J. of The Sci. of Food and Agri 1999; 79.
8. Gaber DM, Nafee N, Abdallah OY. Myricetin solid lipid nanoparticles: Stability assurance from system preparation to site of action. European Journal of Pharmaceutical Sciences 2017.
9. Hong C, Dang Y, Lin G, Yao Y, Li G, Ji G, et al. Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: an in vitro and in vivo evaluation. International Journal of Pharmaceutics 2014; 477: 251–260.
10. Ramadon D, Mun’im A. Utilization of nanotechnology in drug delivery system for natural products. Jurnal Ilmu Kefarmasian Indonesia 2016 14(2):118-127.
11. Rasaie S. Nano phytosomes of quercetin: a promising formulation for the fortification of food products with antioxidants. Pharma Sci 2014; 20:96-101.
12. Jain N, Gupta BP, Thakur N, Jain R, Banweer J, Jain D, et al. Phytosome: a novel drug delivery system for herbal medicine. Int J Pharm Sci Drug Res 2010;2:224-8.
13. Garg R, Kaur S, Ritika, Khatoon S, Naina, Verma H. A Complete And Updated Review On Various Types Of Drug Delivery Systems. Int J of Apllied Prarm 2020;12 (4).
14. Ghanbarzadeh B. Nano-phytosome as a potential food-grade delivery system. Food Biosci 2016; 15:126-35.
15. Pham, Thi T. Colloid and surfaces B: Biointerfaces, liposome and niosome preparation using a membran contractor for scale-up. France 2012; 94:15-21.
16. Indrawati T, Hajard I, Pratami DK. Skincare Cream Preparation And Evaluation Of Pare (Momordica Charantia) Leaves Using Three Difference Base. Int J of Apllied Prarm 2020;12 (6).
17. Harmita H, Iskandarsyah, Murti FZ. Effect Of Transfersome On The Stability And Antioxidant Activity Of Glutathione In Antiaging Creams. Int J of Apllied Prarm 2020;12 (1).
18. Mohanraj VJ, Chen Y. Nanoparticles-a review. J Pharm Res 2006; 5:561-73.
19. Gregoriadis, Gregory. Liposome technology: Liposome preparation and related techniques. Informa Healthcare USA 2007; 3 (1): 21- 32.
20. Juwita AP, Yamlean P, Edy HJ. Formulasi Krim Ekstrak Etanol Daun Lamun (Syringodium isoetifolium). Skripsi, Universitas Sam Ratulangi 2013.
21. Swastika A, Mufrod, Puwanto. Aktivitas Antioksidan Krim Ekstak Sari Tomat (Solanum lycopersicum L.). Trad Med Journal 2013; 18(3): 132 -140.
22. Barokah R. Variasi Harga HLB Emulgator Berdasarkan Perbandingan Tween 80 Dan Span 80 Terhadap Sifat Fisik Dan Kimia Krim Ekstrak Etanol Curcuma Mangga Val Sebagai Sunscreen. Surakarta: Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Sebelas Maret 2014.
Statistics
3 Views | Downloads
Citations
How to Cite
PURNAMASARI, N. A. D., DZAKWAN, M., PRAMUKANTORO, G. E., MAULUDIN, R., & ELFAHMI. (2021). MYRICETIN NANO-PHYTOSOMES PEEL-OFF GEL MASK FORMULATION AS ANTIOXIDANT. International Journal of Applied Pharmaceutics, 13(4). https://doi.org/10.22159/ijap.2021v13i4.40376
Section
Original Article(s)

Most read articles by the same author(s)