MYRICETIN NANO-PHYTOSOMES PEEL-OFF GEL MASK FORMULATION AS ANTIOXIDANT
Keywords:Peel-off gel mask, Myricetin nano-phytosomes, PVA, Antioxidant
Objective: Peel-off gel mask is an alternative preparation which can increase the convenience of use and is expected to increase the antioxidant activity of myricetin nano-phytosomes. Myricetin has various activities, namely as a natural antioxidant, anti-inflammatory, allergy, and anti-cancer. This study aims to determine the nano-phytosome myricetin can be formulated into a gel peel-off mask, determine the concentration of PVA which has the best physical properties of the gel peel-off mask, and determine the antioxidant activity.
Methods: The thin layer hydration method was used to manufacture Myricetin nano-phytosomes, then dried using the freeze-drying method. The resulting nano-phytosome characterization included particle size, polydispersion index, zeta potential and absorption efficiency. Peel-off gel mask were made with variations in the concentration of the PVA gelling agent, namely F1 3.5%, F2 7%, F3 14%. The resulting peel-off gel mask was tested for physical quality including organoleptic test, homogeneity, pH, viscosity, adhesion, drying time and testing for antioxidant activity.
Results: The resulting peel-off gel mask has the good physical quality and met the existing requirements, where the different PVA concentrations resulted in different physical qualities, the higher the PVA, the faster the dry time. All three formulas exhibited very strong antioxidant activity based on DPPH assay with IC50 value of 14.8 ppm (F1), 15.37 ppm (F2), and 15.87 ppm (F3).
Conclusion: Myricetin nano-phytosomes can be formulated into a gel peel-off mask, Formula 2 with a 7% concentration of PVA produces the best physical quality of the peel-off gel mask, the three gel peel-off mask formulas have excellent antioxidant activity.
Pratiwi L, Wahdaningsih S. Formulation and antioxidant activity facial mask gel peel-off papaya fruit methanol extract (Carica papaya L.). Pharm Med J 2008;1. DOI:10.35799/ pmj.1.2.2018.21643.
Armadany FI, Hasnawati, Sirait M. Antioxidant peel-off gel mask formulation from tomato extract (Solanum lycopersicum L. var. cucurbita). Pharm Pharm Sci Health Magazine 2020;2:29-32.
Rahmawanty D, Yulianti N, Fitriana M. Formulation and evaluation of peel-off face masks containing quercetin with various gelatin concentrations. J Med Farm 2015;12:17-32.
Hasyim N, Faradiba, Gina AB. Formulation of wuluh starfruit juice gel (Averrhoa bilimbi L.). Pharm Pharmacol Magazine 2011;15:5-9.
Chakraborty S, Vadakkekara A, George N, Bhagyasree T, Mary L. Application and stability evaluation of polymer blends in cosmetics. Int J Res Appl Sci Eng Tech 2017;5:849-61.
Andre B. Green clay and oleo vera peel of facial masks: response surface methodology applied to the formulation design. Am Assoc of Pharm Sci 2013;14:445-455.
Anese M, Lara M, Maria CN. Antioxidant properties of tomato juice as accented by heating. J Sci Food Agric 1999;79:750-4.
Gaber DM, Nafee N, Abdallah OY. Myricetin solid lipid nanoparticles: Stability assurance from system preparation to site of action. Eur J Pharm Sci 2017;109:569-80.
Hong C, Dang Y, Lin G, Yao Y, Li G, Ji G, et al. Effects of stabilizing agents on the development of myricetin nanosuspension and its characterization: an in vitro and in vivo evaluation. Int J Pharm 2014;477:251–60.
Ramadon D, Mun’im A. Utilization of nanotechnology in drug delivery system for natural products. JIFI 2016;14:118-27.
Rasaie S. Nano phytosomes of quercetin: a promising formulation for the fortification of food products with antioxidants. Pharm Sci 2014;20:96-101.
Jain N, Gupta BP, Thakur N, Jain R, Banweer J, Jain D, et al. Phytosome: a novel drug delivery system for herbal medicine. Int J Pharm Sci Drug Res 2010;2:224-8.
Garg R, Kaur S, Ritika, Khatoon S, Naina, Verma H. A complete and updated review on various types of drug delivery systems. Int J Apllied Pharm 2020;12:1-16.
Ghanbarzadeh B. Nano-phytosome as a potential food-grade delivery system. Food Biosci 2016;15:126-35.
Pham, Thi T. Colloid and surfaces B: Biointerfaces, liposome and niosome preparation using a membran contractor for scale-up. France 2012;94:15-21.
Indrawati T, Hajard I, Pratami DK. Skincare cream preparation and evaluation of pare (Momordica Charantia) leaves using three difference base. Int J Appl Pharm 2020;12:162-6.
Harmita H, Iskandarsyah, Murti FZ. Effect of transfersome on the stability and antioxidant activity of glutathione in antiaging creams. Int J Appl Pharm 2020;12:149-55.
Mohanraj VJ, Chen Y. Nanoparticles-a review. J Pharm Res 2006;5:561-73.
Gregoriadis, Gregory. Liposome technology: liposome preparation and related techniques. Informa Healthcare USA 2007;3:21-32.
Juwita AP, Yamlean P, Edy HJ. Seagrass leaf ethanol extract cream formulation (Syringodium isoetifolium). Thesis Sam Ratulangi University; 2013.
Swastika A, Mufrod, Puwanto. Antioxidant activity of tomato extract cream (Solanum lycopersicum L.). Trad Med J 2013;18:132-40.
Barokah R. HLB emulgator price variation based on comparison of tween 80 and span 80 against physical and chemical properties of Curcuma mangga Val ethanol extract cream as sunscreen. Surakarta: Faculty of Mathematics and Natural Sciences, Sebelas Maret University; 2014.