FORMULATION AND IN VITRO EVALUATION OF RAMELTEON TABLETS FOR COLON DRUG DELIVERY SYSTEM BY COMPRESSION COATING
Objective: Ramelteon, is a sleep agent that selectively binds to the MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN), instead of binding to GABAA receptors. In the present research work formulation of ramelteon targeted to colon by using various polymers developed.
Method: Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit RLPO and L100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques.
Results: The tablets were passed all the tests. Among all the formulations F4 formulation was found to be optimized as it was retarded the drug release up to 18 hours and showed maximum of 99.25% drug release. It followed first order kinetics mechanism.
Conclusion: An effective and stable remelteon colon targeted formulation developed for treating insomnia.
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