KLUTUK BANANA (MUSA BALBISIANA COLLA) PEEL FRACTIONS: ANTIOXIDANT AND ANTIHYPERGLYCEMIC POTENTIAL

  • TITA NOFIANTI Department of Pharmacology, Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia, Department of Pharmacology, Institute of Health Science of Bakti Tunas Husada Tasikmalaya, West Java, Indonesia
  • AHMAD MUHTADI Department of Pharmacology, Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia
  • IRDA FIDRIANNY Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Indonesia
  • AI SAMROTUL FUADAH Department of Pharmacology, Institute of Health Science of Bakti Tunas Husada Tasikmalaya, West Java, Indonesia
  • VERA NURVIANA Department of Pharmacology, Institute of Health Science of Bakti Tunas Husada Tasikmalaya, West Java, Indonesia
  • RUSWANTO Department of Pharmacology, Institute of Health Science of Bakti Tunas Husada Tasikmalaya, West Java, Indonesia

Abstract

Objective: The purposes of this research were the antihyperglycemic and antioxidant determination of klutuk banana peel fractions through the oral glucose tolerance test (OGTT) and DPPH (2,2-diphenyl-1-picrylhydrazyl) methods, respectively.


Methods: Klutuk banana peel was extracted by reflux method and followed by fractionation using n-hexane and ethyl acetate solvents by liquid-liquid extraction method. The statistical analysis used by one-way ANOVA and post hoc Tukey.


Results: The results of OGTT showed that ethyl acetate fraction of klutuk banana peel 14.5 mg/kg bw demonstrated higher activity to decrease blood glucose level compared to the other groups as much-32%,-49%,-47% and-40% at min 30, 60, 90 and 120, respectively. The IC50 of ethyl acetate fraction of klutuk banana peel was 0.3708 µg/ml, and its antioxidant activity index (AAI) 40.45.


Conclusion: The ethyl acetate fraction of klutuk peel presented very strong antioxidant and antihyperglycemic activity.

Keywords: Antihyperglycemic, Antioxidant, Musa balbisiana Colla, Klutuk banana peel

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NOFIANTI, T., MUHTADI, A., FIDRIANNY, I., FUADAH, A. S., NURVIANA, V., & RUSWANTO. (2021). KLUTUK BANANA (MUSA BALBISIANA COLLA) PEEL FRACTIONS: ANTIOXIDANT AND ANTIHYPERGLYCEMIC POTENTIAL. International Journal of Applied Pharmaceutics, 13(2), 1-6. https://doi.org/10.22159/ijap.2021.v13s2.01
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