COMPARISON OF ANTIHYPERGLYCEMIC ACTIVITY OF DIFFERENT PARTS OF KLUTUK BANANA (MUSA BALBISIANA COLLA)

Authors

  • TITA NOFIANTI Department of Pharmacology, Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia, Department of Pharmacology, Institute of Health Science of Bakti Tunas Husada Tasikmalaya, West Java, Indonesia
  • AHMAD MUHTADI Department of Pharmacology, Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia
  • IRDA FIDRIANNY Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Indonesia

DOI:

https://doi.org/10.22159/ijap.2021.v13s3.12

Keywords:

Antihyperglycemic, Musa balbisiana, Antioxidant, Different parts, OGTT

Abstract

Objective: Banana is a plant that grows in Indonesia and is widely consumed by Indonesian people. One of banana type is klutuk banana (Musa balbisiana Colla). There were many types of researches about klutuk banana for antidiabetic activity; however, antidiabetic activity of its peel and pulp are still unknown.

Methods: The objective of the study was to determine of antihyperglycemic activity of different parts of klutuk banana. Animals were divided into 15 groups, namely normal control, negative control, positive control (glibenclamide 0.65 mg/kg body weight (bw), and 12 sample groups. All animals were given 2 g/kg bw glucose monohydrate and blood glucose level was measured every 30 min for 120 min.

Results: The results of the oral glucose tolerance test (OGTT) showed that KPE2 (klutuk peel extract 350 mg/kg bw) gave higher activity to decrease blood glucose level compared to the other groups at the minute of 30 (-24.83%; p. 0.00), 60 (-33.93%; p. 0.000), 90 (-46.29%; p. 0.000) and 120 (-35.44%; p. 0.000).

Conclusion: The klutuk peel extract has very strong antioxidant activity and antihyperglycemic activity at a dose of 350 mg/kg bw.

References

1. Salam N, Fareed M, Khoja AT, Mahmoud AM, Ahamed M. Life style related risk factors of type 2 diabetes mellitus and its increased prevalence in Saudi Arabia: a brief review utilization of clinical preventive services among Saudi older adults view project lifestyle related risk factors of type 2 diabetes. Int J Med Res Heal Sci 2017;6:125–32.
2. Ligita T, Wicking K, Francis K, Harvey N, Nurjannah I. How people living with diabetes in Indonesia learn about their disease: a grounded theory study. PLoS ONE 2019;14:1-19.
3. Internasional of Diabetic Ferderation (IDF). IDF Diabetes Atlas-8th Edition; 2017. Available from: www.diabetesatlas.org. [Last accessed on 15 Aug 2020]
4. Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract 2018;4:271-81.
5. Indonesian Health Ministry. Basic health research of the ministry of health; 2018. p. 1-200.
6. MacBryde, Bruce. Consensus document on the biology of bananas and plantains (Musa sp.) Vol. 43. Paris. OECD Environment Health Safety Publications 2009;43:1-87.
7. Borah M, Das S. Antidiabetic, antihyperlipidemic, and antioxidant activities of Musa balbisiana colla. in type 1 diabetic rats. Indian J Pharmacol 2017;49:71–6.
8. Deka P, Kashyap A, Sharma D, Baruah C. A review on Musa balbisiana colla. Int J Pharm Sci Invent 2018;7:14-7.
9. Tin HS, Padam BS, Kamada T, Vairappan CS, Abdullah MI, Chye FY. Isolation and structure elucidation of triterpenes from inflorescence of banana (Musa balbisiana cv. saba). Int Food Res J 2016;23:866-72.
10. Shian TE, Abdullah A, Musa KH, Maskat MY, Ghani MA. Antioxidant properties of three banana cultivars (Musa acuminate berangan, mas and raja) extracts. Sains Malaysiana 2012;41:319-24.
11. Navghare VV, Dhawale SC. In vitro antioxidant, hypoglycemic and oral glucose tolerance test of banana peels. Alexandria Med J 2017;53:237-43.
12. Ighodaro OM, Adeosun AM, Asejeje FO, Soetan GO, Kassim OO. Time course effects of 5,5-dihydroxylpyrimidine-2,4,6-trione (alloxan) as a diabetogenic agent in animal model. Alexandria Med J 2018;54:705–10.
13. Ighodaro OM, Adeosun AM, Akinloye OA. Review alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina 2017;53:365-74.
14. Malpani MO, Rajput PR, Chinchole KV, Kapse SS, Ambarkar KS. Phytochemical screening and antioxidant activity of extracts of Xanthium strumarium, Chrysanthemum and their mixture. Rasayan J Chem 2019;12:1901–8.
15. Tchimene MK, Okoli CO, Iwu MM. Antidiabetic property of some Nigerian medicinal plants. J Med Plants Res 2016;10:139-48.
16. Oskouei BG, Ravasjani SA, Musavinejad SJ, Salehzadeh SA, Abdolhosseinzadeh A, Hamishehkar H, et al. In vivo evaluation of anti-hyperglycemic, anti-hyperlipidemic and antioxidant status of liver and kidney of thymol in STZ-induced diabetic rats. Drug Res (Stuttg) 2019;69:46-52.
17. Gopalan G, Prabha B, Joe A, Reshmitha TR, Sherin DR, Abraham B, et al. Screening of Musa balbisiana colla. seeds for antidiabetic properties and isolation of apiforol, a potential lead, with antidiabetic activity. J Sci Food Agric 2019;99:2521–9.
18. Bisht AJ, Juyal D, Monika, Verma S, Joshi S. Study on in vitro antidiabetic potential of stem part of Musa paradisiaca linn. Antimicrobial and phytochemical analysis of leaf extract of medicinal fruit plants. Int J Compr Adv Pharmacol 2017;2:1-5.
19. Verma S, Sahdev AK, Raj V. Stem of Musa paradisiaca (linn.) shows the inhibitory effect towards alpha-amylase and alpha-glucosidase enzymes: antidiabetic activity. Adv Tissue Eng Regen Med 2017;2:164?6.
20. Nguyen D, Novakova A, Spurna K, Hricko J, Phung H, Viktorova J, et al. Antidiabetic compounds in stem juice from banana. Czech J Food Sci 2017;35:7–13.
21. Borborah K, Borthakur SK, Tant B. Musa balbisiana Colla taxonomy, traditional knowledge and economic potentialities of the plant in Assam, India. Indian J Trad Knowledge 2016;15:116-20.
22. Jannat K, Morshed Md Z, Akter S, Rahmatullah M. Improved oral glucose tolerance with ripe fruit peels of Musa seminifera lour. Arch Nat Med Chem 2018;13:1-4.
23. Genatrika E, Laksari VNH, Tjiptasurasa. Antidiabetic activity of Musa acuminata colla fruit peel (MACFP) ethanol extract in glucose-induced diabetic rats. MATEC Web Conf 2018;197:1-4.
24. Al-Mahamud R, Jannat K, Islam M, Shova NA, Jahan R, Hossain Md N, et al. Variations in oral glucose tolerance is present in different sub-cultivars of fruit skins of Musa sapientum L (banana). World J Pharm Res 2018;7:192-9.
25. Murthy SSN, Felicia C. Antidiabetic activity of Musa sapientum fruit peel on STZ induced diabetic rats. Int J Pharm Bio Sci 2015;6:537–43.
26. Gozali D, Mustarichie R. Antidiabetic activity of ethanol extract of ranggap bananas Musa troglodytarum L. Int Res J Pharm 2018;9:80-4.
27. Scherer R, Godoy HT. Antioxidant activity index (AAI) by the 2,2-diphenyl-1-picrylhydrazyl method. Food Chem 2009;112:654-8.
28. Rosdiana R. Fortification of tofu using antioxidants from kepok banana peel extract (Musa bluggoe). repository.upi.edu; 2014.
29. Wardati F, Holil K, Syarifah U. Cytotoxicity test on breast cancer cell lines T-47D treated with pisang kepok peel extract (Musa balbisiana). J Trop Life Sci 2018;1:84-8.
30. Fidrianny I, Rizki K, Insanu M. In vitro antioxidant activities from various extracts of banana peels using ABTS, DPPH assays and correlation with phenolic, flavonoid, carotenoid content. Int J Pharm Pharm Sci 2014;6:299-303.
31. Fidrianny I, Sefiany E, Ruslan K. In vitro antioxidant activities from three organs of white ambon banana (Musa AAA Group) and flavonoid, phenolic, carotenoid content. Int J Pharmacogn Phytochem Res 2015;7:590-6.
32. Haripyaree A, Guuneshwor K, Damayanti M. Evaluation of antioxidant properties of some wild edible fruits extracts by cell-free assays. Elec J Env Agricult Food Chem 2010;9:345-450.
33. Yin X, Quan J, Kanazawa T. Banana prevents plasma oxidative stress in healthy individuals. Plant Foods Hum Nutr 2008;63:71-6.
34. Qusti SY, Abo Khatwa AN, Lahwa MA. Free radical scavenger enzymes of fruit plant species cited in Holy Quran. World Appl Sci J 2010;9:338-44.
35. Saritha M. Flavonoids-the most potent poly-phenols as antidiabetic agents: an overview. Mod Appro Drug Des 2017;1:1-5.
36. Rebelloa LPG, Ramosb AM, Pertuzattic PB, Barciad MT, Munoze NC, Gutierrezf IH. Flour of banana (Musa AAA) peel as a source of antioxidant phenolic compounds. Food Res Int 2014;55:397-403.
37. Marianne, Yuandani, Rosnani. Antidiabetic activity from ethanol extract of Kluwih’s leaf (Artocarpus camansi). J Natural 2011;11:64-8.
38. Vijayakumar S, Presannakumar G, Vijayalakshmi NR. Investigations on the effect of flavonoids from banana, Musa paradisiaca L. on lipid metabolism in rats. J Diet Suppl 2009;6:111-23.

Published

2021-03-10

How to Cite

NOFIANTI, T., MUHTADI, A., & FIDRIANNY, I. (2021). COMPARISON OF ANTIHYPERGLYCEMIC ACTIVITY OF DIFFERENT PARTS OF KLUTUK BANANA (MUSA BALBISIANA COLLA). International Journal of Applied Pharmaceutics, 13(3), 57-61. https://doi.org/10.22159/ijap.2021.v13s3.12

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