FLOATING MULTIPLE UNIT MINITABLETS OF METOPROLOL SUCCINATE: FORMULATION, IN VITRO AND IN VIVO CHARACTERIZATION

Authors

  • MADHULITA PANDA Roland Institute of Pharmceutical Sciences, Berhampur 760010, Ganjam, Odisha
  • M. E. BHANOJI RAO Roland Institute of Pharmceutical Sciences, Berhampur 760010, Ganjam, Odisha
  • JNYANARANJAN PANDA Roland Institute of Pharmceutical Sciences, Berhampur 760010, Ganjam, Odisha
  • C. H. NIRANJAN PATRA Roland Institute of Pharmceutical Sciences, Berhampur 760010, Ganjam, Odisha
  • GANESH PATRO College of Pharmaceutical Sciences, Mohuda, Ganjam, Odisha, India

DOI:

https://doi.org/10.22159/ijap.2021v13i3.41066

Keywords:

Gelucire 4301, Bioavailability, Stability, Floating lag time

Abstract

Objective: In this present research, formulation of floating multiple unit minitablets of metoprolol succinate without using gas generating agent was attempted with an objective of increased residence time, sustained release, and improved oral bioavailability.

Methods: Solid dispersions were prepared with lipophilic carriers such as compritol ATO888, Gelucire 43/01, Gelucire 39/01, and precirol ATO 05 was formulated using fusion technique. Neusillin US2 was used as an adsorbent. The solid dispersions were compressed into minitablets, weighing 20 mg, and then filled into ‘0’ size capsule.

Results: Formulation F9, F10, F14, and F15 showed instantaneous floating lag time, i.e., 0 min, floating time more than 12 h, and sustained release up to 12 h. Pharmacokinetic study of the optimized formulation (F9) showed 2.46 times increase in area under the curve with increased residence time.

Conclusion: Hence gelucire 43/01 based floating multiple unit minitablets of metoprolol succinate can be considered a promising approach.

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Published

07-05-2021

How to Cite

PANDA, M., RAO, M. E. B., PANDA, J., PATRA, . C. H. N., & PATRO, G. (2021). FLOATING MULTIPLE UNIT MINITABLETS OF METOPROLOL SUCCINATE: FORMULATION, IN VITRO AND IN VIVO CHARACTERIZATION. International Journal of Applied Pharmaceutics, 13(3), 130–136. https://doi.org/10.22159/ijap.2021v13i3.41066

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