PREPARATION AND EVALUATION OF A TASTE-MASKED ARTEMETHER ORAL SUSPENSION

Authors

  • SHITAL JAYANT BIDKAR Research Scholar, Biju Patnaik University of Technology, Odisha, India, Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
  • M. E. BHANOJI RAO Research Guide, Roland Institute of Pharmaceutical sciences, Berhampur, Odisha, India, Research Guide, Roland Institute of Pharmaceutical sciences, Berhampur, Odisha, India
  • GANESH Y. DAMA Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
  • JAYANT S. BIDKAR Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
  • PRADNYA S. NAYKODI Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India

Keywords:

artemether, Taste-masked, Oral Suspension

Abstract

Objective

The antimalarial drug Artemether is bitter in taste. The purpose of this work is to construct a taste-masked Artemether resinate employing ion exchange resins.

 

Methodology

The process for drug resin complexation was adjusted in terms of drug resin ratio and medium pH. FTIR and DSC measurements were used to characterise the taste masked complex. As an ion exchange resin, Indion 204 was used. It was combined with medication in various ratios: Indion was generated at various times and pH values and the extent of complexation was determined.

 

Results

The result indicates that a 1:1 ratio of Indion 204 to resin resulted in the largest amount of complexation after four hours of mixing. These resinate then converted into granules and they exhibit angle of repose, bulk density, and flow characteristic values that are acceptable. The loading of drugs was greater than 99 percent. Based on drug content, suitable amount of drug-resinate was taken for formulation. Then Suspension was studied for general appearance, viscosity, sedimentation ratio, drug release, resuspendability. The release test showed that 92.46% drug release within 120 min.

 

Conclusion

Hence we can conclude that, the Indion 204 has been proved to be useful as taste masking agent. Thus we are able to achieve our objectives of preparing taste masked suspension of Artemether with minimum excipients and simple method of manufacturing. 

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Published

21-06-2022

How to Cite

BIDKAR, S. J., RAO, M. E. B., DAMA, G. Y., BIDKAR, J. S., & NAYKODI, P. S. (2022). PREPARATION AND EVALUATION OF A TASTE-MASKED ARTEMETHER ORAL SUSPENSION. International Journal of Applied Pharmaceutics, 14. Retrieved from https://innovareacademics.in/journals/index.php/ijap/article/view/45554

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