• SHITAL JAYANT BIDKAR Research Scholar, Biju Patnaik University of Technology, Odisha, India, Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
  • M. E. BHANOJI RAO Research Guide, Roland Institute of Pharmaceutical sciences, Berhampur, Odisha, India, Research Guide, Roland Institute of Pharmaceutical sciences, Berhampur, Odisha, India
  • GANESH Y. DAMA Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
  • JAYANT S. BIDKAR Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India
  • PRADNYA S. NAYKODI Sharadchandra Pawar College of Pharmacy, Otur, Pune, Maharashtra, India


artemether, Taste-masked, Oral Suspension



The antimalarial drug Artemether is bitter in taste. The purpose of this work is to construct a taste-masked Artemether resinate employing ion exchange resins.



The process for drug resin complexation was adjusted in terms of drug resin ratio and medium pH. FTIR and DSC measurements were used to characterise the taste masked complex. As an ion exchange resin, Indion 204 was used. It was combined with medication in various ratios: Indion was generated at various times and pH values and the extent of complexation was determined.



The result indicates that a 1:1 ratio of Indion 204 to resin resulted in the largest amount of complexation after four hours of mixing. These resinate then converted into granules and they exhibit angle of repose, bulk density, and flow characteristic values that are acceptable. The loading of drugs was greater than 99 percent. Based on drug content, suitable amount of drug-resinate was taken for formulation. Then Suspension was studied for general appearance, viscosity, sedimentation ratio, drug release, resuspendability. The release test showed that 92.46% drug release within 120 min.



Hence we can conclude that, the Indion 204 has been proved to be useful as taste masking agent. Thus we are able to achieve our objectives of preparing taste masked suspension of Artemether with minimum excipients and simple method of manufacturing. 


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Nasr NEH., ElMeshad AN, Fares AR. Nanocarrier Systems in Taste Masking. Scientia Pharmaceutica. 2022;90(1):20.

Lopalco A, Manni A, Keeley A, Haider S, Li W, Lopedota A, Altomare CD, Denora N, Tuleu C. In Vivo Investigation of (2-Hydroxypropyl)-β-cyclodextrin-Based Formulation of Spironolactone in Aqueous Solution for Paediatric Use. Pharmaceutics. 2022 Apr 3;14(4):780. doi: 10.3390/pharmaceutics14040780. PMID: 35456614; PMCID: PMC9029429.

Andrew EC, Grace EA, Elochukwu UC, Ezinne OC, Eze K. Formulation and Development of Controlled Drug Delivery of Artemether Using Biopolymer. Journal of Drug Design and Medicinal Chemistry. 2022;8(1):1-10.

Wolska E, Brach M. Distribution of Drug Substances in Solid Lipid Microparticles (SLM)-Methods of Analysis and Interpretation. Pharmaceutics. 2022 Jan 31;14(2):335. doi: 10.3390/pharmaceutics14020335. PMID: 35214067; PMCID: PMC8879661.

Zheng X, Wu F, Hong Y, Shen L, Lin X, Feng Y. Developments in Taste-Masking Techniques for Traditional Chinese Medicines. Pharmaceutics. 2018 Sep 12;10(3):157. doi: 10.3390/pharmaceutics10030157. PMID: 30213035; PMCID: PMC6161181.

Pawar S, Shende P. A comparative outlook on pharmacokinetics and antimalarial studies of artemether and lumefantrine-loaded microneedle patches and a dry suspension containing nanosponges. Journal of Drug Delivery Science and Technology, 60, 102055.

Naik J, Rajput R, Singh MK. Development and evaluation of ibuprofen loaded hydrophilic biocompatible polymeric nanoparticles for the taste masking and solubility enhancement. Bio Nano Science. 2021;11(1), 21-31.

Pluijm RWV, Tripura R, Hoglund RM, Phyo AP, Lek D, Ul Islam A, Valeche, N. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial. The Lancet. 2020;395(10233):1345-1360.

Rao MRP, Bhutada K, Kaushal P. Taste Evaluation by Electronic Tongue and Bioavailability Enhancement of Efavirenz. AAPS PharmSciTech. 2019 Jan 7;20(2):56. doi: 10.1208/s12249-018-1277-8. PMID: 30617434.

Nandhini J, Rajalakshmi AN. Dispersible tablets: A review. J Pharm Adv Res, 2018; 1(3): 148-155.

Faisal W, Farag F, Abdellatif AAH, Abbas A. Taste Masking Approaches for Medicines. Curr Drug Deliv. 2018 Feb 14;15(2):167-185. doi: 10.2174/1567201814666171013145958. PMID: 29034835.



How to Cite

BIDKAR, S. J., RAO, M. E. B., DAMA, G. Y., BIDKAR, J. S., & NAYKODI, P. S. (2022). PREPARATION AND EVALUATION OF A TASTE-MASKED ARTEMETHER ORAL SUSPENSION. International Journal of Applied Pharmaceutics, 14. Retrieved from



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