FORMULA OPTIMIZATION AND IN VITRO RELEASE KINETIC STUDIES OF DILTIAZEM HYDROCHLORIDE MUCOADHESIVE BILAYER BUCCAL FILM

  • LINA WINARTI Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jember, 68121, Indonesia
  • AFALAH ZULFA LAILY Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jember, 68121, Indonesia
  • LUSIA OKTORA RUMA KUMALA SARI Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jember, 68121, Indonesia
  • EKA DEDDY IRAWAN Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jember, 68121, Indonesia
  • DWI NURRAHMANTO Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jember, 68121, Indonesia
  • VIDDY AGUSTIAN ROSYIDI Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jember, 68121, Indonesia
  • KUNI ZUAIMAH BARIKAH Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jember, 68121, Indonesia
  • LIDYA AMELIANA Department of Pharmaceutics, Faculty of Pharmacy, University of Jember, Jember, 68121, Indonesia

Abstract

Objective: This research aims to determine the amount of hydroxypropyl methylcellulose (HPMC) and chitosan, which can produce the optimum buccal film formula and to determine the release kinetics of diltiazem hydrochloride in vitro.


Methods: The film was prepared by the solvent casting method. The formula's optimization was carried out using factorial design, which was processed using Design Expert 11.0.0 software, while the release kinetics was analyzed using the DDSolver program.


Results: The optimization results show that HPMC and chitosan (30 mg: 10 mg) is the amount of polymer that can produce the optimum formula. The buccal film formula has a swelling index of 2.92, a mucoadhesive strength of 64.40 gF, and a mucoadhesive residence time of 464 min. In vitro release study showed 97.64% release of Diltiazem hydrochloride after 480 min. The release kinetic’s of diltiazem hydrochloride follow the Korsmeyer Peppas model.


Conclusion: Thus, it can be concluded that the prepared formulation of the buccal mucoadhesive film can be a delivery system for diltiazem hydrochloride.

Keywords: Mucoadhesive bilayer buccal film, Diltiazem hydrochloride, HPMC, Chitosan, Factorial design

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WINARTI, L., LAILY, A. Z., SARI, L. O. R. K., IRAWAN, E. D., NURRAHMANTO, D., ROSYIDI, V. A., BARIKAH, K. Z., & AMELIANA, L. (2021). FORMULA OPTIMIZATION AND IN VITRO RELEASE KINETIC STUDIES OF DILTIAZEM HYDROCHLORIDE MUCOADHESIVE BILAYER BUCCAL FILM. International Journal of Applied Pharmaceutics, 13(2), 7-12. https://doi.org/10.22159/ijap.2021.v13s2.02
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