CHARACTERIZATION AND CONCENTRATION OPTIMIZATION OF HIBISCUS ROSA-SINENSIS L. MUCILAGE POWDER AS SUPERDISINTEGRANT
Objective: The main purpose of this study is to characterize Hibiscus rosa-sinensis L. mucilage (MHR) powder as superdisintegrant and to decide the optimum concentration of Hibiscus rosa-sinensis L.
Methods: Characterization was conducted in many tests such as organoleptic, swelling ratio, solubility, polysaccharide, viscosity, particle size distribution, flowability and compressibility index. Next, MHR powder was included in fast disintegrating tablet (FDT) domperidone formulation in several concentrations and compared with FDT domperidone formulation that using sodium starch glycolate as superdisintegrant.
Results: The result of characterization of MHR powder were brownish powder, specific smell like traditional medicines, swelling ratio of 24, solubility of 0.426±0.034 mg/ml, positive polysaccharide, the viscosity of 491.33±119.44 cps (2% w/v), 4520.00±1224.42 cps (4% w/v), Dv(10) of 26.2 µm, Dv(50) of 157 µm, Dv(90) of 260 µm, Dv(100) of 380 µm, flowless, and average compressibility index of 26.75±1.79%. The optimum MHR powder concentration was 1% because the average disintegration time was 39.67±4.73 seconds and the average wetting time was 66.33±14.29 seconds. Those times were faster than domperidone FDT that used this superdisintegrant in other concentrations or sodium starch glycolate in the same concentration.
Conclusion: Hibiscus rosa-sinensis L. mucilage powder can be used as superdisintegrant in FDT formulation with an optimum concentration of 1%.
2. Ameena K, Dilip C, Saraswathi R, Krishnan PN, Sanker C, Simi SP. Isolation of the mucilages from Hibiscus rosa-sinensis L. and Okra (Abelmoschus esculentus L.) and studies of the binding effects of the mucilages. Asian Pac J Trop Med 2010;3:539-43.
3. Bhowmik D, Chiranjib B, Krisnakanth, Pankaj, Margret RC. Fast dissolving tablet: an overview. J Chem Pharm Res 2009;1:163-77.
4. Dfepharma. Superdisintegrants: introduction to chemistry and performance. Germany: Dfepharma; 2012.
5. Bhatia NM, Salunkhe SS, Mali SM, Gadkari SS, Hajare, Gaikwad SV, et al. Extraction and characterization of mucilage from Lepidium sativum L. seeds. School Res Lib Der Pharm Lett 2014;6:65-70.
6. Parikh DM. Handbook of pharmaceutical granulation technology. New York: Marcel Dekker Inc; 1997.
7. The United States Pharmacopeia Convention. The united states pharmacopeia. 30th ed. Rockville (MD): The United States Pharmacopeia Convention; 2007.
8. Indonesia’s Ministry of Health. Farmakope Indonesia Edisi V. Jakarta: Indonesia’s Ministry of Health; 2014.
9. Bala R, Shailesh S, IKGPTU. Formulation and evaluation of fast dissolving tablet of aprepitant by using natural and synthetic superdisintegrants. Int J Appl Pharm 2020;12:64-71.
10. Spigno G, Lorenzo T, Dante MDF. Effect of extraction time, temperature and solvent on concentration and antioxidant activity of grape marc phenolics. J Food Eng 2007;81:200-8.
11. Pahwa R, Nisha G. Superdisintegrants in the development of orally disintegrating tablets: a review. Int J Pharm Sci Res 2011;2:2767-80.
12. Priyanka S, Vandana S. A review article on: superdisintegrants. Int J Drug Res Tech 2013;3:76-87.
13. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. 2nd ed. Philadelphia: Lea and Febiger; 1986.
14. Smallenbroek AJ, Bolhuis GK, Lerk CF. The effect of particle size of disintegrants on the disintegration of tablets. Pharm Weekbl 1981;3:1048-51.
15. Dhahir RK, Al-Kotaji M. Formulation of orally disintegrating tablets of cinnarizine by using direct compression method. Int J Appl Pharm 2019;11:117-23.
This work is licensed under a Creative Commons Attribution 4.0 International License.