DESIGN, OPTIMIZATION, AND EVALUATION OF RAFT FORMING GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF LAFUTIDINE USINGBOX–BEHNKEN DESIGN

Authors

  • LANKALAPALLI SRINIVAS Department of Pharmaceutics, GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam 530045, Andhra Pradesh, India https://orcid.org/0000-0002-6918-8297
  • SHANTI SAGAR Department of Pharmaceutics, GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam 530045, Andhra Pradesh, India

DOI:

https://doi.org/10.22159/ijap.2022v14i1.43358

Keywords:

: Lafutidine, anti-ulcer, gastro-retentive, Box–Behnken design (BBD),buoyancy lag-time, zero-order release.

Abstract

Objective: The current research was aimed to formulate and evaluate raft forming gastro retentive floating drug delivery systems of Lafutidine for improving gastric residence time and sustained drug release for an extended time.

Methods: Using Box–Behnken experimental design 17 formulations of lafutidine GRDDS were designed and evaluated for various parameters like physical appearance, pH, In-vitro gelling study, in-vitro buoyancy study, measurement of viscosity, density measurement, gel strength, drug content, acid neutralization capacity, the profile of neutralization, in-vitro dissolution, release kinetic and stability studies.

Results: All the evaluations were performed and observed that the values were within range, and the buoyancy lag time ranged within 14.76 to 25.84 sec and the formulations remained buoyant for more than 8h with the gelling time of 12h, the drug content was ranging from 98.96 to 99.55 %, and in-vitro release was 86.86 to 99.34% by the end of 12h. The release kinetics followed zero-order with Higuchi’s model that indicating that drug release was found to be followed by the matrix diffusion process.

Conclusion: Out of all formulations F3 was the optimized formulation and it was further characterized for FTIR, DSC, and stability studies, which exposed that there were no interactions amongst drug and excipients and no major change in the formulation and found to be stable.

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Published

22-11-2021

How to Cite

SRINIVAS, L., & SAGAR, S. (2021). DESIGN, OPTIMIZATION, AND EVALUATION OF RAFT FORMING GASTRO RETENTIVE DRUG DELIVERY SYSTEM OF LAFUTIDINE USINGBOX–BEHNKEN DESIGN. International Journal of Applied Pharmaceutics, 14(1). https://doi.org/10.22159/ijap.2022v14i1.43358

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Original Article(s)