DEVELOPMENT AND EVALUATION OF RAFT FORMING GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEM OF NIZATIDINE BY DESIGN OF EXPERIMENT

Authors

  • SHANTI SAGAR GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam 530045, Andhra Pradesh, India https://orcid.org/0000-0002-6918-8297
  • LANKALAPALLI SRINIVAS GITAM Institute of Pharmacy, GITAM (Deemed To Be University), Rushikonda, Visakhapatnam 530045, Andhra Pradesh, India https://orcid.org/0000-0002-6918-8297

DOI:

https://doi.org/10.22159/ijap.2022v14i2.43728

Keywords:

Nizatidine, Histamine H2antagonist, Box-Behnken design, Gel strength, viscosity, Release kinetics.

Abstract

Objective: The current research involves the formulation of a sustained-release gastro-retentive drug delivery system of nizatidine.

Methods: Using 33 Box-Behnken designs, about 17 experiments were performed and evaluated for various parameters like physical appearance, pH, in-vitro gelling study, in-vitro buoyancy study, measurement of viscosity, density measurement, gel strength, raft resilience, drug content, acid neutralization capacity, in-vitro dissolution, release kinetics and stability studies.

Results: All the formulations exhibited good viscosity, density less than gastric fluid, gelling capacity retained, and buoyant for 12 h. Drug content ranges from 97.98 to 99.34 % with a long neutralization period. The buoyancy lag time was found to be in the range of 15.34 to 26.12 sec and the % drug release at 12 h was between range from 85.67 to 99.45 with the highest release exhibited by F3. All formulations displayed zero order in vitro drug release > 10 h with exceptional buoyancy properties. F3 was the optimized formulation and further subjected to FTIR & DSC study, concluding that compatibility of nizatidine with excipients in the formulation blend. Stability studies show no significant changes.

Conclusion: Results indicate that gastric-floating formulations of nizatidine have the prospective for superior gastric residence time and sustained drug release.

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Published

15-01-2022

How to Cite

SAGAR, S., & SRINIVAS, L. (2022). DEVELOPMENT AND EVALUATION OF RAFT FORMING GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEM OF NIZATIDINE BY DESIGN OF EXPERIMENT. International Journal of Applied Pharmaceutics, 14(2). https://doi.org/10.22159/ijap.2022v14i2.43728

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Original Article(s)