• VINOD KUMAR Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences and Research, Jamia Hamdard, PO Hamdard Nagar 110062, New Delhi
  • BRITO RAJ S. Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam 603103, Chengalpattu District, Tamilnadu https://orcid.org/0000-0001-5987-3031
  • LAKSHMI KANAKARAJ Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam 603103, Chengalpattu District, Tamilnadu
  • DEEVAN PAUL A. Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam 603103, Chengalpattu District, Tamilnadu
  • KAVITHA K. NITTE College of Pharmaceutical Sciences, Bangaluru 560064, Karnataka
  • RAVI M. Jaya College of Paramedical Sciences, Thiruninravur, Chennai 602024
  • SUCHARITHA P. Seven Hills College of Pharmacy, Chittoor, Tirupati 517561, Andhra Pradesh




Aptamer, SELEX, Biosensors, Novel drug delivery system, Nanoparticle, Diagnosis


In recent year, Aptamer has been one of the key tools in the field of advanced drug delivery systems. Aptamer are oligonucleotides or peptides that bind to a specific target molecule. In this review we summarize the major differences between the antibody and an Aptamer along with the different methodology of the In vitro selection of the Aptamer by using SELEX (Systematic evolution of ligands by exponential enrichment) technique. SELEX is a technique which has a based biosensors and some of the novel drug delivery system. The article referred in this review was referred from the above said source was in the range of 1990-2020 years.

Primary contents is searched from science direct, springer nature, scopus indexed journals. The resources are downloaded from google scholar, peer-reviewed published literature from scientific journals and books.

Search criteria: The primary contents are searched from science direct, springer nature, scopus indexed journals. The resources are downloaded from google scholar, peer-reviewed published literature from scientific journals and books.


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Capra, John A, Paeschke, Katrin, Singh, Mona, Zakian, Virginia A. Stormo, Gary D. G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae. PLOS Computational Biology.2010;6: e1000861.

Ellington AD and Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature. 1990; 346: 818–22.

Gold L, Janjic N, Jaruis T, Schneider D, Walker JJ, Wilcox SK, Zinchi D. Aptamer and RNA world past and present. Cold Spring Harb Perspect Biol 2012; 4:1-9.

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Yanling Song, Jia Song, Xinyu Wei, Mengjiao Huang, Miao Sun. Discovery of Aptamer Targeting the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein. Anal Chem. 2020; 92: 9895–900.

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How to Cite

KUMAR, V., RAJ S., B., KANAKARAJ, L., PAUL A., D., K., K., M., R., & P., S. (2022). APTAMER: A REVIEW ON ITS IN VITRO SELECTION AND DRUG DELIVERY SYSTEM. International Journal of Applied Pharmaceutics, 14(2). https://doi.org/10.22159/ijap.2022v14i2.43594



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