ANTICANCER ACTIVITY OF SILVER NANOPARTICLE OF PRODIGIOSIN ON LUNG CANCER
Keywords:Prodigiosin, Lung cancer, Serratia marcenscens, Silver nanoparticles.
Objective: Nanotechnology is a relatively new branch of science and technology that studies and controls the interactions of synthetic and biological materials. Researchers are becoming more interested in nanoparticles as a result of their vast medicinal potential, particularly against cancer.
Methods: The Serratia marcescens culture supernatant containing Prodigiosin was used to synthesize silver nanoparticles in an environmentally benign biogenic manner. The effect of nanoparticles on the growth and proliferation of human lung cancer cell (A549) in vitro was investigated in this work. MTT Assay and DNA fragmentation assay were used to characterize the nanoparticles that had been produced.
Results: Cytotoxicity of the Prodigiosin AgNPs was represented as IC50 value of 31.2µg/ml and the viability decrease in the number of nanoparticles-treated cells. DNA fragmentation assay showed the degradation of DNA.
Conclusion: The present study conforms as the synthesized Prodigiosin AgNPs can be a promising anticancer agent regarding its mechanism of action.
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