• HARSHA KOREDDI University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510
  • VIDYADHARA SURYADEVARA Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur 522019
  • BALAKRISHNA TALAMANCHI Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur 522019
  • RAMU ANNE Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur 522019





Objective: The current research involves the formulation of a sustained-release gastro-retentive drug delivery system of nizatidine.

Methods: Using 33 Box-Behnken designs, about 17 experiments were performed and evaluated for various parameters like physical appearance, pH, in-vitro gelling study, in-vitro buoyancy study, measurement of viscosity, density measurement, gel strength, raft resilience, drug content, acid neutralization capacity, in-vitro dissolution, release kinetics and stability studies.

Results: All the formulations exhibited good viscosity, density less than gastric fluid, gelling capacity retained, and buoyant for 12 h. Drug content ranges from 97.98 to 99.34 % with a long neutralization period. The buoyancy lag time was found to be in the range of 15.34 to 26.12 sec and the % drug release at 12 h was between range from 85.67 to 99.45 with the highest release exhibited by F3. All formulations displayed zero order in vitro drug release > 10 h with exceptional buoyancy properties. F3 was the optimized formulation and further subjected to FTIR & DSC study, concluding that compatibility of nizatidine with excipients in the formulation blend. Stability studies show no significant changes.

Conclusion: Results indicate that gastric-floating formulations of nizatidine have the prospective for superior gastric residence time and sustained drug release.


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Eberle VA, Schoelkopf J, Gane PA, Alles R, Huwyler J, Puchkov M. Floating gastroretentive drug delivery systems: Comparison of experimental and simulated dissolution profiles and floatation behavior. Eur J Pharm Sci. 2014 Jul 16;58: 34-43.

Pahwa R, Saini N, Kumar V, Kohli K. Chitosan-based gastroretentive floating drug delivery technology: an updated review. Expert Opin Drug Deliv. 2012 May;9(5):525-39

Mandel KG, Daggy BP, Brodie DA, Jacoby HI. Review article: alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment Pharmacol Ther. 2000 Jun; 14(6):669-90.

Arianto, A., H. Bangun, A. Yohana, and J. Silalahi. “Floating gastroretentive of amoxicillin using hard alginate capsules and its antibacterial activities”. Asian J of Pharm and Clin Res, vol. 10, no. 5, May 2017, pp. 414-20,

Badhan AC, Mashru RC, Shah PP, Thakkar AR, Dobaria NB. Development and evaluation of sustained release gastroretentive minimatrices for effective treatment of H. pylori infection. AAPS Pharm SciTech. 2009; 10(2):459-67.

Sathiyaraj S, Devi RD, Hari VB. Lornoxicam gastro retentive floating matrix tablets: Design and in vitro evaluation. J Adv Pharm Technol Res. 2011 Jul;2(3):156-62.

Sanjay, K. M., and M. K. Gupta. "Characterization and Evaluation of Nizatidine Floating Microsphere based drug delivery system for antiulcer activity." Int J of Pharm Sci & Res 10 2019 10; 4557-4567.

Darwish MKM, Abu El-Enin ASM, Mohammed KHA. Formulation, optimization, and evaluation of raft-forming formulations containing Nizatidine. Drug Dev Ind Pharm. 2019 Apr;45(4):651-663.

Ranch KM, Maulvi FA, Naik MJ, Koli AR, Parikh RK, Shah DO. Optimization of a novel in situ gel for sustained ocular drug delivery using Box-Behnken design: In vitro, ex vivo, in vivo and human studies. Int J Pharm. 2019 Jan 10;554:264-275

Abou Youssef NA, Kassem AA, El-Massik MA, Boraie NA. Development of gastroretentive metronidazole floating raft system for targeting Helicobacter pylori. Int J Pharm. 2015;486(1-2):297-305

Abouelatta SM, Aboelwafa AA, El-Gazayerly ON. Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug. Drug Deliv. 2018 Nov;25(1):1161-1174.

Abbas G, Hanif M, Khan MA. pH responsive alginate polymeric rafts for controlled drug release by using box behnken response surface design. Des Monomers Polym. 2016 Sep 11;20(1):1-9.

Abbas G, Hanif M, Shah S, Zaman M. Raft-forming system for pantoprazole and domperidone delivery: in vitro and in vivo study. Bioinsp Biomimetic and Nano biomat. 2019: 1-10.

Karemore, MN Avari, JG. In-situ gel of nifedipine for preeclampsia: Optimization, in-vitro and in-vivo evaluation. J Drug Deliv Sci Technol.2019; Apr 50, 78-89

Dettmar PW, Gil-Gonzalez D, Fisher J, Flint L, Rain forth D, Moreno-Herrera A, Potts M. A comparative study on the raft chemical properties of various alginate antacid raft-forming products. Drug Dev Ind Pharm. 2018 Jan;44(1):30-39.

Pashikanti, S., & B., J. Formulation and evaluation of floating in situ gel of ciprofloxacin. Int J of App Pharm, 201911; 1, 198–204.

M, S. S.; Priya, S.; Maxwell, A. Formulation and evaluation of novel in situ gel of lafutidine for gastro retentive drug delivery. Asian J Pharm Clin Res 2018, 11, 88-94.

Patel, D. M.; Patel, D. G.; Patel, C. N. Formulation and optimization of raft forming chewable tablet containing lafutidine. Int. J. Pharm. Sci. Drug Res. 2015, 7, 229-234.

Hao J, Fang X, Zhou Y, Wang J, Guo F, Li F, Peng X. Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design. Int J Nanomedicine. 2011;6:683-92

Orugonda K, Reddy V and Reddy S D Pectin as a release retardant in gas generating floatable system of nizatidine - preparation and evaluation. J global trends pharm sci, 2017; 8(1): 3554 – 3563.

Alhamdany AT, abbas AK. Formulation and in vitro evaluation of amlodipine gastroretentive floating tablets using a combination of hydrophilic and hydrophobic polymers. Int j appl pharm. 2018; 10(6):126–34.

Mazumder R, Nath K L, Haque A, Maity T, Choudhuy KP, Shrestha B, Chakraborty M AND Pal N Formulation and in vitro evaluation of natural polymers based microspheres for colonic drug delivery. Int J of Pharm and Pharma Sci. 2010:1, 2; 211-219



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