POTENTIAL OF HERBAL MEDICINE IN ASIA FOR ORAL CANDIDIASIS THERAPY: A SYSTEMATIC REVIEW

Authors

  • ANI MEGAWATI Oral Medicine Specialist Program, Faculty of Dentistry, Universitas Padjadjaran, Jl. Sekeloa Selatan no 1, Bandung, West Java, Indonesia 40132
  • INDAH SUASANI WAHYUNI Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Jl. Sekeloa Selatan no 1, Bandung, West Java, Indonesia 40132

DOI:

https://doi.org/10.22159/ijap.2021.v13s4.43794

Keywords:

Herbal medicine, Antifungal, Oral candidiasis, Candida albicans

Abstract

The objective of this review was to provide antifungal recommendations for Oral Candidiasis (OC) derived from herbal medicine based on the research results of the last 5 y. This systematic review was conducted according to Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines using the PubMed and Science Direct databases with studies published between 2016 and 2021. The review was conducted on 13 studies, in vitro and clinical trial. A total of 41 species of plants have studied its antifungal effects on Candida albicans. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) varied in the range of 0.098 µl/ml to 125 µl/ml for different types of plants and Candida samples, while the mean inhibition zone (ZOI) was 11 mm. The most recommended herbal medicine for the development of antifungal drugs for oral candidiasis therapy were Nigella sativa, Lawsonia inermis, and Zingiber officinale.

Downloads

Download data is not yet available.

References

Vila T, Sultan AS, Montelongo Jauregui D, Jabra Rizk MA. Oral candidiasis: A disease of opportunity. J Fungi (Basel). 2020;6(1):1-28. doi: 10.3390/jof6010015, PMID 31963180.

Garcia Cuesta C, Sarrion Perez MG, Bagan JV. Current treatment of oral candidiasis: A literature review. J Clin Exp Dent. 2014;6(5):e576-82. doi: 10.4317/jced.51798, PMID 25674329.

Carolus H, Pierson S, Lagrou K, Van Dijck P. Amphotericin B and other polyenes-discovery, clinical use, mode of action and drug resistance. J Fungi (Basel). 2020;6(4):1-20. doi: 10.3390/jof6040321, PMID 33261213.

Tocci N, Perenzoni D, Iamonico DF, Weil T, Mattivi F. Extracts from Hypericum hircinum subsp. majus exert antifungal activity against a panel of sensitive and drug-resistant clinical strains. Front Pharmacol. 2018;9(Apr):1-10.

Freires Ide A, Murata RM, Furletti VF, Sartoratto A, Alencar SM, Figueira GM, de Oliveira Rodrigues JA, Duarte MC, Rosalen PL. Coriandrum sativum L. (Coriander) essential oil: antifungal activity and mode of action on Candida spp., and molecular targets affected in human whole-genome expression. PLOS One. 2014;9(6):e99086. doi: 10.1371/journal.pone.0099086, PMID 24901768.

Silva JP, Peres AR, Paixão TP, Silva AS, Baetas AC, Barbosa WL, Monteiro MC, Andrade MA. Antifungal activity of hydroalcoholic extract of Chrysobalanus icaco against oral clinical isolates of Candida species. Pharmacognosy Res. 2017;9(1):96-100. doi: 10.4103/0974-8490.199772, PMID 28250661.

Stojkovic D, Dias MI, Drakulic D, Barros L, Stevanovic M, CFR Ferreira ICFR, D Sokovic M. Methanolic extract of the herb Ononis spinosa L. is an antifungal agent with no cytotoxicity to primary human cells. Pharmaceuticals. 2020;13(4):1-13. doi: 10.3390/ph13040078.

Suurbaar J, Mosobil R, Donkor AM. Antibacterial and antifungal activities and phytochemical profile of leaf extract from different extractants of Ricinus communis against selected pathogens. BMC Res Notes. 2017;10(1):660. doi: 10.1186/s13104-017-3001-2, PMID 29191226.

Vediyappan G, Dumontet V, Pelissier F, d’Enfert C. Gymnemic acids inhibit hyphal growth and virulence in Candida albicans. Plos One. 2013;8(9):e74189. doi: 10.1371/journal.pone.0074189, PMID 24040201.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Br Med J. 2021;372. doi: https://doi.org/10.1136/bmj.n71

Miller SA, Forrest JL. Enhancing your practice through evidence-based decision making: PICO, learning how to ask good questions. J Evidenced-Based Dent Pract. 2001;1(2):136-41.

Kim SY, Park JE, Lee YJ, Seo HJ, Sheen SS, Hahn S, Jang BH, Son HJ. Testing a tool for assessing the risk of bias for nonrandomized studies showed moderate reliability and promising validity. J Clin Epidemiol. 2013;66(4):408-14. doi: 10.1016/j.jclinepi.2012.09.016, PMID 23337781.

Sajjadi ST, Saboora A, Mohammadi P. Comparison of aglycon and glycosidic saponin extracts of Cyclamen coum tuber against Candida spp. Curr Med Mycol. 2016;2(2):40-4. doi: 10.18869/acadpub.cmm.2.2.7, PMID 28681019.

Hovijitra RS, Choonharuangdej S, Srithavaj T. Effect of essential oils prepared from Thai culinary herbs on sessile candida albicans cultures. J Oral Sci. 2016;58(3):365-71. doi: 10.2334/josnusd.15-0736, PMID 27665976.

Aghazadeh M, Zahedi Bialvaei A, Aghazadeh M, Kabiri F, Saliani N, Yousefi M, Eslami H, Samadi Kafil H. Survey of the antibiofilm and antimicrobial effects of zingiber officinale (In vitro study). Jundishapur J Microbiol. 2016;9(2):e30167. doi: 10.5812/jjm.30167. PMID 27127591.

Sharma H, Yunus GY, Agrawal R, Kalra M, Verma S, Bhattar S. Antifungal efficacy of three medicinal plants Glycyrrhiza glabra, Ficus religiosa, and Plantago major against oral Candida albicans: A comparative analysis. Indian J Dent Res. 2016;27(4):433-6. doi: 10.4103/0970-9290.191895, PMID 27723643.

Soliman SSM, Semreen MH, El-Keblawy AA, Abdullah A, Uppuluri P, Ibrahim AS. Assessment of herbal drugs for promising anti-candida activity. BMC Complement Altern Med. 2017;17(1):257. doi: 10.1186/s12906-017-1760-x, PMID 28482836.

Al-Thobity AM, Al-Khalifa KS, Gad MM, Al-Hariri M, Ali AA, Alnassar T. In vitro evaluation of the inhibitory activity of thymoquinone in combatting Candida albicans in denture stomatitis prevention. Int J Environ Res Public Health. 2017;14(7):1-9. doi: 10.3390/ijerph14070743, PMID 28698449.

Naeini A, Shayegh SS, Shokri H, Davati A, Khazaei A, Akbari A. In vitro antifungal effect of herbal mixture (Nigella sativa, Foeniculum vulgare and Camellia sinensis) against candida species isolated from denture wearers. J HerbMed Pharmacol. 2017;6(2):74-9.

Bhat V, Sharma SM, Shetty V, Shastry CS, Rao CV, Shenoy S, Saha S, Balaji S. Characterization of herbal antifungal agent, Origanum vulgare against oral Candida spp. Isolated from patients with candida-associated denture stomatitis: an in vitro study. Contemp Clin Dent. 2018;9(5):11-9. doi: 10.4103/ccd.ccd_537_17.

Samadi FM, Suhail S, Sonam M, Sharma N, Singh S, Gupta S, Dobhal A, Pradhan H. Antifungal efficacy of herbs. J Oral Biol Craniofac Res. 2019;9(1):28-32. doi: 10.1016/ j.jobcr.2018.06.002, PMID 30197861.

Nosratzehi T, Nosratzehi M, Nosratzehi S, Lotfi F. The comparison of the effect of curcumin with nystatin on inhibition level of Candida albicans. J Exp Pharmacol. 2019;11:93-7. doi: 10.2147/JEP.S215843, PMID 31496837.

Ariamanesh H, Tamizi N, Yazdinezhad A, Salah S, Motamed N, Amanloo S. The effectiveness of Nigella sativa alcoholic extract on the inhibition of Candida albicans colonization and formation of plaque on acrylic denture plates: an in vitro study. J Dent (Shiraz). 2019;20(3):171-7. doi: 10.30476/ DENTJODS.2019.44911, PMID 31579691.

Zainal M, Mohamad Zain N, Mohd Amin I, Ahmad VN. The antimicrobial and antibiofilm properties of allicin against Candida albicans and staphylococcus aureus- A therapeutic potential for denture stomatitis. Saudi Dent J. 2021;33(2):105-11. doi: 10.1016/j.sdentj.2020.01.008, PMID 33551624.

Ghorbani A, Sadrzadeh A, Habibi E, Dadgar K, Akbari J, Moosazadeh M, Hossein B, Ahangarkani F, Vaezi A. Efficacy of Camellia sinensis extract against candida species in patients with denture stomatitis. Curr Med Mycol. 2018;4(3):15-8. doi: 10.18502/cmm.4.3.174, PMID 30619964.

Rodríguez Hernandez CO, Castillo FYR, Olvera C, Muro AL. Cell culture: history, development and prospects. Int J Curr Res Acad Rev. 2014;2(12):188-200.

Ansari MA, Fatima Z, Hameed S. Anticandidal effect and mechanisms of monoterpenoid, perillyl alcohol against candida albicans. PLOS ONE. 2016;11(9):e0162465. doi: 10.1371/ journal.pone.0162465, PMID 27627759.

Teodoro GR, Ellepola K, Seneviratne CJ, Koga-Ito CY. Potential use of phenolic acids as anti-candida agents: a review. Front Microbiol. 2015;6(12):1420. doi: 10.3389/fmicb.2015.01420, PMID 26733965.

Published

11-12-2021

How to Cite

MEGAWATI, A., & WAHYUNI, I. S. (2021). POTENTIAL OF HERBAL MEDICINE IN ASIA FOR ORAL CANDIDIASIS THERAPY: A SYSTEMATIC REVIEW. International Journal of Applied Pharmaceutics, 13(4), 1–6. https://doi.org/10.22159/ijap.2021.v13s4.43794

Issue

Section

Review Article(s)