INTERLEUKIN AS BIOMARKER OF RECURRENT APHTHOUS STOMATITIS (RAS): A SYSTEMATIC LITERATURE REVIEW

Authors

  • INDAH DAMAYANTI Undergraduate Program of Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang km 21, Jatinangor, Sumedang, West Java, 45363
  • NANAN NUR’AENY Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Jl. Sekeloa Selatan no 1, Bandung, West Java, Indonesia 40132
  • INDAH SUASANI WAHYUNI Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Jl. Sekeloa Selatan no 1, Bandung, West Java, Indonesia 40132

DOI:

https://doi.org/10.22159/ijap.2021.v13s4.43813

Keywords:

Interleukin, Recurrent aphthous stomatitis, Biomarker, Gene polymorphism

Abstract

This review aimed to describe the interleukins and interleukin gene polymorphisms related to and recommended as a RAS biomarker. Articles were searched through PubMed, ScienceDirect, and Cochrane Library databases, using the keywords of “Interleukin” AND “Recurrent Aphthous Stomatitis”. The Risk of Bias Assessment tool for Non-randomized Studies (RoBANS) was used, and the writing of this review refers to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. A total of 8 articles met the criteria and showed a low risk of bias assessment. The level of IL-2, IL-6, IL-8, and IL-18 in the acute clinical phase of RAS were higher than in the recovery phase, but IL-10 levels showed decreased. IL-2, IL-6, IL-10 gene polymorphisms were found to be more frequent in RAS patients compared to controls, while IL-12 gene polymorphisms were found to be less associated with RAS pathogenesis. Interleukins at the proteomic level that recommended as a pro-inflammatory biomarker are IL-2, IL-6, IL-8, IL-12, and IL-18, while an anti-inflammatory is IL-10. Only IL-2 can be recommended as a biomarker at the genomic level, as other interleukins still require more investigation.

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Published

11-12-2021

How to Cite

DAMAYANTI, I., NUR’AENY, N., & WAHYUNI, I. S. (2021). INTERLEUKIN AS BIOMARKER OF RECURRENT APHTHOUS STOMATITIS (RAS): A SYSTEMATIC LITERATURE REVIEW. International Journal of Applied Pharmaceutics, 13(4), 27–33. https://doi.org/10.22159/ijap.2021.v13s4.43813

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Section

Review Article(s)