SINGLE-NUCLEOTIDE POLYMORPHISM OF TNFSF4 (RS2205960) OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN BANDUNG, INDONESIA

Authors

  • ANGELA APRILIA KARYADI Department Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
  • ERICA WILLY Department Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
  • GABRIEL BAGUS KENNARDI Immunology Study Center, Faculty of Medicine, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
  • MUHAMMAD SYAWAL PRATAMA Department of Pharmacology and Clinical Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
  • DESI RESKI FAJAR Department Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
  • LANIYATI HAMIJOYO Immunology Study Center, Faculty of Medicine, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia, Department of Internal Medicine Faculty of Medicine, Padjadjaran University, Hasan Sadikin Hospital, Jl. Pasteur 38 Bandung, 40161, Indonesia
  • RIEZKI AMALIA Department of Pharmacology and Clinical Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia
  • MELISA INTAN BARLIANA Department Biological Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor, 45363, Indonesia

DOI:

https://doi.org/10.22159/ijap.2021.v13s4.43827

Keywords:

Bandung, Single-nucleotide polymorphism, RS2205960, Systemic lupus erythematosus, TNFSF4

Abstract

Objective: This study aimed to determine the genotype distribution of the TNFSF4 (Tumor Necrosis Factor Superfamily 4) gene rs2205960 in Systemic Lupus Erythematosus (SLE) patients in Bandung, West Java, Indonesia.

Methods: This was a cross-sectional study; 84 genomic DNA samples were amplified, electrophoresed, then analyzed by DNA sequencing.

Results: The genotype distribution of the TNFSF4 gene rs2205960 in SLE patients showed that from 84 DNA samples, 55 patients are GG (65.48%), 25 patients are GT (29.76%), and 4 patients are TT (4.76%).

Conclusion: Results indicate that SLE patients in Bandung have a genotype distribution of the TNFSF4 rs2205960 gene that fulfills the Hardy-Weinberg equilibrium.

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Published

11-12-2021

How to Cite

KARYADI, A. A., WILLY, E., KENNARDI, G. B., PRATAMA, M. S., FAJAR, D. R., HAMIJOYO, L., AMALIA, R., & BARLIANA, M. I. (2021). SINGLE-NUCLEOTIDE POLYMORPHISM OF TNFSF4 (RS2205960) OF SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS IN BANDUNG, INDONESIA. International Journal of Applied Pharmaceutics, 13(4), 106–111. https://doi.org/10.22159/ijap.2021.v13s4.43827

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