• MEGHNA DABHADKAR SCES’s Indira College of Pharmacy, Mumbai Bangalore Highway, Tathawade, Pune, India 411033
  • MADHUR KULKARNI SCES’s Indira College of Pharmacy, Mumbai Bangalore Highway, Tathawade, Pune, India 411033



dentin hypersensitivity, thermoreversible sol-gel, potassium nitrate, poloxamer, chitosan


Objective: The objective of the present study was to develop an in situ gelling formulation of potassium nitrate for the treatment of dentin hypersensitivity (DH).

Methods: Formulation was optimized using 32 full factorial design, wherein concentration of two gelling agents poloxamer 407 and chitosan (90% deacetylation) were the independent variables and formulation viscosity, and gelation time were dependent variables. The trial formulations were evaluated for pH, spreadability, drug content, adherence time, and in vitro drug release; apart from viscosity and gelation time.

Results: The optimized formulation containing 22% of poloxamer 407 and 0.5 % of chitosan exhibited the gelation time of less than 150 s, viscosity of about 2450 cps, and thermoreversible sol-gel transition behaviour. The novel in situ gel showed a pH of 4.58, spreadability as 5.55 and adherence time 4.3 h. The formulation could sustain the drug release over a period of 4 h and it was found to be 81.83 ±1.03%.   Accelerated stability studies conducted over 3 months duration ensured good physical and chemical stability of the formulation.

Conclusion: The optimized in situ gel formulation of potassium nitrate in the sol state is expected to allow easy and site specific administration on the sensitive tooth. Upon application, the temperature sensitive sol would get converted to a gel that would improve its retention time on the sensitive tooth and extend the duration of therapeutic action by sustaining the drug release.


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