THE FORMULATION OF NANOEMULSION SERUM-CONTAINING GOTU KOLA EXTRACT (CENTELLA ASIATICA L. URBAN) AND CHIA SEED OIL (SALVIA HISPANICA) FOR SKIN HYDRATION EFFECT
Keywords:Nanoemulsion, Centella asiatica, Asiaticoside, Chia seed, Hydration, Serum, Cosmetic
Objective: The aims of this study of nano serum formulation from C. asiatica and chia seed to skin hydration effect.
Methods: C. asiatica extraction was macerated by 70% ethanol and evaporated by a rotary evaporator to produce high viscosity of extract yields. Four different formulas were obtained from nanoemulsion serum production with different concentrations of chia seed oil (1%, 2%, 3%, 4%). Two formulas F1 (1% chia seed oil) and F4 (4% chia seed oil) were selected for further clinical testing, which were applied at face skin for 7 d, then were measured using a skin analyzer looking for the best and most effective.
Results: Optimation result of extraction method of C. asiatica herb as high as 28.74% extract yields and 3.12% asiaticoside content. The result value of formulation based on the effect of moisturizing/hydration then can be analyzed with the Minitab program using the One-way ANOVA method. The result indicated that the product can increase face skin moistness at 20 respondents, where 13.36% increase from F1 formula and 13.88% increase from F4 formula.
Conclusion: The nanoemulsion serum-containing combination of C. asiatica extract and chia seed oil enables to increase in the moisturizing effect on dry skin or normal tend to dry skin.
Esthetico derma institute Indonesia. Handbook for professionals in aesthetic treatment. 2nd ed. Semarang: Esthetico derma institute Indonesia; 2011.
Baumann L. Cosmetic dermatology: principles and practice. 2nd ed. New York: McGraw-Hill Companies; 2009.
Wijayadi LY, Darmawan H. Asiaticoside increases aquaporin-3 protein expression in the cytoplasm of normal human epidermal keratinocytes. UnivMed. 2017;36(1):25. doi: 10.18051/UnivMed.2017.v36.25-33.
Das A. Advances in chia seed research. AIBM. 2017 Aug;5(3). doi: 10.19080/AIBM.2017.05.555662.
Wathoni N, Haerani A, Yuniarsih N, Haryanti R. A review on herbal cosmetics in Indonesia. Int J App Pharm. 2018;10(5):13-6. doi: 10.22159/ijap.2018v10i5.28102.
Zulkarnaen O, Putri A, Eka, Ekstrak Etanol PKA. % Pegagan (Centella asiatica) menggunakan metode LC–MS. J Ilm Farm. 2009;70:99-107.
Pramono S, Ajiastuti D. Standardisasi ekstrak herba pegagan (Centella asiatica.(L.). Urban) berdasarkan kadar asia-tikosida secara KLT-densitometri Standardization of pegagan extract (Centella asiatica (L.) Urban) based on asiaticoside content using TLC-densitometric method. Maj. Farmaco Indones. 2004;15:118-23.
De Falco B, Amato M, Lanzotti V. Chia seeds products: an overview. Phytochem Rev. 2017;16(4):745-60. doi: 10.1007/s11101-017-9511-7.
Gupta PK, Pandit JK, Kumar A, Swaroop P, Gupta S. Pharmaceutical nanotechnology novel nanoemulsion–high energy emulsification preparation, evaluation and application. Pharm Res. 2010:117-38.
Devarajan V, Ravichandran V, Masilamani K. Development, characterization, and in vitro evaluation of telmisartan nanoemulsion. Int J Front Sci Technol. 2013;1:75-86.
Utami SS. Formulasi dan uji penetrasi in vitro nanoemulsi, nanoemulsi gel, dan gel Kurkumin. Skripsi, no. Depok: Universitas Indonesia; 2012. p. 16-21.
Departemen kesehatan republik Indonesia, Farmakope Herbal Indonesia. 1st ed. Departemen Kesehatan Republik Indonesia; 2008.
Jeong SK, Park HJ, Park BD, Kim IH. Effectiveness of topical chia seed oil on pruritus of end-stage renal disease (ESRD) patients and healthy volunteers. Ann Dermatol. 2010;22(2):143-8. doi: 10.5021/ad.2010.22.2.143, PMID 20548903.
How to Cite
Copyright (c) 2022 SELLY KARLINA, CHAIDIR, YUNAHARA FARIDA
This work is licensed under a Creative Commons Attribution 4.0 International License.