DESIGN AND DEVELOPMENT OF PHYTOSOMAL SOFT NANOPARTICLES FOR LIVER TARGETING

Authors

  • MANJUSHA A. BHANGE Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India 442001 https://orcid.org/0000-0003-4332-9474
  • ANIL PETHE Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India 442001
  • ANKITA HADKE Department of Pharmaceutics, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India 442001 https://orcid.org/0000-0001-7163-0307

DOI:

https://doi.org/10.22159/ijap.2023v15i1.46303

Keywords:

Ferulic acid, Conjugation, Complex formation, Solvent evaporation method, Nanoparticle, Drug targeted system, Bioavailability

Abstract

Objective: The objective of the study was to design and formulate ferulic acid phytosomes converted in to functionalised soft nanoparticles by using solvent evaporation method to increase resistance time, improve bioavailability, and half-life of ferulic acid.

Methods: Ferulic acid is a BCS-II drug,  which has low solubility and high permeability. The functionalised soft nanoparticles was prepared by the solvent evaporation method followed by the particle size and zeta potential, FTIR, PXRD, SEM. It indicates good result for the complexation rate. PXRD showed good powder diffraction results with having good flow property. Particle size and zeta potential had a good result of -12.05±120 improved by the cationic polymer. The complex was evaluated by the study of Drug loading, Entrapment efficiency, Histopathological study and mucoadhesive property for the final formulation of the microspheres system. Also formulation were evaluated for the In-vitro drug dissolution study for rate of extent of drug release. Ex-vivo drug diffusion study by using goat nasal mucosa using pH 6.6 for evaluating rate of extent of drug diffusion through nasal mucosa.

Results: The results of the characterization studies indicated the designing of functionalised phytosomal soft nanoparticles. The functionalised phytosomal soft nanoparticles (FPSN) particle size and zeta potential had a good result of -12.05±120. The FTIR spectra of complex showed characteristic peak at 3652.8 cm-1 (OH-stretching) which indicate that the shifting and interaction between the drug and phospholipids SPC 3. PXRD, SEM, in-vitro dissolution showed good powder diffraction results with having good flow property. The complex is evaluated by the study of Drug loading. Also formulation were evaluated for the In vitro drug   dissolution study for rate of extent of drug release. The result ofabove studies was Drug loading increased at 44.42 %. ex-vivo permeation study FALC-MS showed characteristic in the drug diffusion at 80.04 % which indicate that the drug had increases its aqueous solubility and also change with the structural morphology.

Conclusion: It can be concluded that the ferulic acid phytosomal soft nanoparticles enhance the solubility of the ferulic acid and increased the bioavailability and retention time to target the liver cancer.

Keywords: Ferulic Acid,  Conjugation, Complex Formation, Solvent evaporation technique, Nanoparticle, Drug targeted systems, Bioavailability.

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Published

04-11-2022

How to Cite

A. BHANGE, M., PETHE, A., & HADKE, A. (2022). DESIGN AND DEVELOPMENT OF PHYTOSOMAL SOFT NANOPARTICLES FOR LIVER TARGETING. International Journal of Applied Pharmaceutics, 15(1). https://doi.org/10.22159/ijap.2023v15i1.46303

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