FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF OMEPRAZOLE


Piyush Jain, R. N. Gupta, Sandeep Shrivastava

Abstract


Objective: The aim of present study is to formulate mouth dissolving tablet of omeprazole, the drug will be directly absorbed into systemic circulation through buccal mucosa and lead to produce immediate action.

Methods: Mouth dissolving tablets of Omeprazole were prepared by wet granulation method. Required quantity of drug and other excipients were weighed and sieved from sieve no.60 for finding homogenous mixer, then a damp mass of mixer was prepared by using distilled water as a solvent, Damp mass was passed through sieve no. 10 and dried the granules at 50 °C till moisture remaining less than 2%

Results: All the formulated tablets met the pharmacopoeias standard of uniformity of weight, percentage friability, thickness, and drug content. The in vitro disintegration and dispersion studies were also performed, which shows very good bioavailability and drug release profile.

Accelerated stability studies were done for four weeks and found that no significant change in drug content and other parameters like hardness and in vitro dispersion time after four weeks even at 50 °C. It may be predicted that formulation will be stable for more than one year.

Conclusion: The present investigation successfully formulated mouth dissolving tablets of omeprazole with improved drug release profile. The formulation was chosen because it showed good results in terms of cumulative drug release, disintegration time, hardness and friability. The dissolution study of this formulation showed an increase in the cumulative % drug release.

Keywords: Mouth dissolving tablets, Omeprazole, Bioavailability, Hepatic first pass metabolism, Wet granulation method, Carr’s index

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References


H Seager. Drug-delivery products and the Zydis fast-dissolving dosage. J Pharm Pharmacol 1998;50:375-82.

SS Biradar, ST Bhagavati, IJ Kuppuasad. Fast dissolving drug delivery system: a brief overview. Internet J Pharmcol 2006;4:467-76.

W Habib, R Khankari, J Hontz. Fast-dissolve drug delivery system. Crit Rev Ther Drug Carrier Syst 2000;17:61-72.

SR Parakh, AV Gothoskar. A review of mouth dissolving tablet technologies. J Pharm Pharmacol 1998;50:375-82.

BS Kuchekar, AC Badhan, HS Mahajan. Mouth dissolving tablets: a novel drug delivery system. Pharm Times 2003;35:7–9.

S Nail, L Galtin. Freeze drying: principles and practices. In: KE Avis, HA Lieberman. Eds. Pharmaceutical dosage forms-parenteral medication, Marcel Dekker Inc., New York; 1993. p. 163-233.

R Bogner, F Meghan. Fast dissolving tablets, US Pharmacist; 2005. p. 27.

M Gohel, M Patel, R Agarwal, A Amin, R Dave, N Bariya. Formulation design and optimization of mouth dissolving tablets of nimesulide using vacuum drying technique. AAPS PharmSciTech 2004;36:5.

M Adel, M Semreen, K Oato. Superdisintegrants for solid dispersion to produce rapidly disintegrating tenoxicam tablets via camphor sublimation. Pharm Technol 2005;13:241-7.

J Remon, S Corveleyn. Formulation and production of rapidly disintegrating tablets by lyophilization using hydrochlorothiazide as a model drug. Int J Pharm 1997;152:215–25.

G Gregory, J Peach, J Mayna. Article for carrying chemicals. United States Patent 1983;4:371, 516.

D Gole, R Levison, J Carbone. Preparation of pharmaceutical and another matrix system by solid-state dissolution. United States Patent 1993;5:215, 756.

KG Van Scoik. Solid pharmaceutical dosage in tablet triturates form and method of producing the same. United States Patent 1992;5:882, 667.

K Masaki. Intrabuccally disintegrating preparation and production thereof. United States Patent 1995;5:466-4.

W Pebley, N Jagar, S Thomnson. Rapidly disintegrating tablets. United States Patent 1994;5:298, 261.

T Mishra, J Currington, S Kamath, P Sanghvi, J Sisak, M Raiden. Fast dissolving comestible units formed under speed/high-pressure conditions. The United States 1999;5:869, 898.

G Myer, G Battist, R Fuisz. Process and apparatus for making rapidly dissolving dosage unit and product therefrom. United States Patent 1999;5:866, 163.

L Augsburger, A Brzeczko, U Shah. Superdisintegrants: characterization and function. In: J Swarbrick, JC Boylan. Eds. Encyclopedia of pharmaceutical technology, Marcel Dekker Inc., New York; 2002. p. 2623-37.

Zhao LL. Augsburger, Functionality comparison of 3 classes of super disintegrants in promoting aspirin tablet disintegration and dissolution. AAPS PharmSciTech 2005;6:634-40.




About this article

Title

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF OMEPRAZOLE

Date

07-04-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 2, 2016 Page: 48-51

Online ISSN

0975-7066

Statistics

219 Views | 183 Downloads

Authors & Affiliations

Piyush Jain
Bhagyoday Tirth Pharmacy College, Sagar, 470001, M. P.

R. N. Gupta

Sandeep Shrivastava


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