A REVIEW ON TREATMENT AND PREVENTION OF DIABETES MELLITUS

  • Rajni Jain Bhagyoday Tirth Pharmacy College Sagar, 470002
  • Piyush Jain Bhagyoday Tirth Pharmacy College Sagar, 470002
  • Poorva Jain Bhagyoday Tirth Pharmacy College Sagar, 470002

Abstract

Diabetes mellitus is an endocrinological and metabolic disorder with an increasing global prevalence and incidence. High blood glucose levels are symptomatic of diabetes mellitus as a consequence of inadequate pancreatic insulin secretion or poor insulin-directed mobilization of glucose by target cells. Diabetes mellitus is aggravated by and associated with metabolic complications that can subsequently lead to premature death. The diagnosis of diabetes in an asymptomatic subject should never be made on the basis of a single abnormal blood glucose value. For the asymptomatic person, at least one additional plasma/blood glucose test result with a value in the diabetic range is essential, either fasting, from a random (casual) sample, or from the oral glucose tolerance test (OGTT). If such samples fail to confirm the diagnosis of diabetes mellitus, it will usually be advisable to maintain surveillance with periodic re–testing until the diagnostic situation becomes clear. In these circumstances, the clinician should take into consideration such additional factors as ethnicity, family history, age, adiposity, and concomitant disorders, before deciding on a diagnostic or therapeutic course of action. An alternative to blood glucose estimation or the OGTT has long been sought to simplify the diagnosis of diabetes. Diabetes is a metabolic disorder that can be prevented through lifestyle modification, diet control, and control of overweight and obesity. Education of the populace is still key to the control of this emerging epidemic. Novel drugs are being developed, yet no cure is available in sight for the disease, despite new insight into the pathophysiology of the disease.

Keywords: Diabetes mellitus, Insulin, Blood glucose levels, Hyperglycemia, Type1 diabetes, Type2 diabetes

References

1. Salimi. Diabetes mellitus and its treatment. Int J Diabetes Metab 2005;13:111-34.
2. W Kerner, J Brückel. Definition, classification and diagnosis of diabetes mellitus. German Diabetes Associaton 2014;122:384–6.
3. MN Piero, GM Nzaro, JM Njagi. Diabetes mellitus–a devastating metabolic disorder. Asian J Biomed Pharm Sci 2014;4:1-7.
4. National Center for Health Statistics: Current estimates from the National Health Interview Survey, United States, 1992. Vital and Health Statistics; 1994. p. 189.
5. WC Knowler, DJ Pettitt, MF Saad, PH Bennett. Diabetes mellitus in the pima indians incidence, risk factors and pathogenesis. Diabetes Metab Rev 1990;6:1-27.
6. W Kerner, J Brückel. Definition, classification and diagnosis of diabetes mellitus. Int J Pharmacol 2014;122:384–6.
7. BE Metzger l. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358:1991–2002.
8. BE Metzger l. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010;33:676–82.
9. MB Landon. A multicenter, randomized trial of treatment for mild gestational diabetes, N Engl J Med 2009;361:1339–48.
10. AF Amos, DJ McCarty, P Zimmet. The rising global burden of diabetes and its complications; estimates and projections to the year 2010. Diabetic Med 1997;14;S7-S85.
11. P George, B Rudvid. Lipids and diabetes. J Clin Biomed Sci 2000;3;159-62.
12. JM Lawrence, R Contreras, W Chen, DA Sacks. Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among a racially/ethnically diverse population of pregnant women, 1999–2005. Diabetes Care 2008;31;899-904.
13. B Nyholm, N Porksen, CB Juhl, CH Gravholt, PC Butler, J Weeke, et al. Assessment of insulin secretion in relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus; evidence of early beta cell dysfunction, Metabolism 2000;49;896-905.
14. Ramachandran C, Snehalatha V Vijay. Burden of type-2 diabetes and its complications. Indian Scenario, Curr Sci 2002;83;1471-8.
15. S Schwartz, V Fonseca, B Berner. Efficacy, tolerability, and safety of a novel once-daily extended-release metformin in patients with type 2 diabetes. Diabetes Care 2006;29;759-64.
16. American Diabetes Association 1701 North Beauregard Street
Alexandria, VA 223111-800-DIABETES; 2016.
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How to Cite
Jain, R., P. Jain, and P. Jain. “A REVIEW ON TREATMENT AND PREVENTION OF DIABETES MELLITUS”. International Journal of Current Pharmaceutical Research, Vol. 8, no. 3, July 2016, pp. 16-18, https://innovareacademics.in/journals/index.php/ijcpr/article/view/13360.
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Review Article(s)