FREE RADICAL SCAVENGING ACTIVITY OF THE BACOSIDE FRACTION FROM BACOPA MONNIERI


Manoharan Mohana, Palghat Raghunathan Padma

Abstract


Objective: Bacopa monnieri is a herb which has been used in Indian traditional medicine for a long period. Bacosides, the major constituents of Bacopa monnieri, have antioxidant, anticancer and memory enhancing properties.

Methods: The bacoside fraction was isolated from the dried powder of the aerial parts of Bacopa monnieri. The free radical scavenging activity of the bacoside fraction was determined by different assays (DPPH, ABTS, SO, NO, OH and H2O2) at concentrations ranging from 5 µg to 200 µg.

Results: The scavenging activity was increased in a dose-dependent manner from 5µg to 50 µg and a plateau in activity was observed from concentrations higher than 50 µg of the bacoside fraction.

Conclusion: Higher concentrations did not show further increase in scavenging activity. Various in vivo and in vitro studies are needed to assess the medicinal potential of the bacoside fraction

Keywords: Bacopa monnieri, bacoside fraction, and free radical scavenging activity.

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About this article

Title

FREE RADICAL SCAVENGING ACTIVITY OF THE BACOSIDE FRACTION FROM BACOPA MONNIERI

Date

07-04-2016

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Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 2, 2016 Page: 61-64

Online ISSN

0975-7066

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94 Views | 274 Downloads

Authors & Affiliations

Manoharan Mohana
Department of Biochemistry, Biotechnology, and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women University, Coimbatore 641043, Tamil Nadu, India

Palghat Raghunathan Padma
Department of Biochemistry, Biotechnology, and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women University, Coimbatore 641043, Tamil Nadu, India


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